Rabbit RFX1 Polyclonal Antibody | anti-RFX1 antibody

RFX1 Antibody

Cat. Num. AAA9631253

• Gene Names: RFX1; EFC; RFX
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: RFX1; Polyclonal Antibody; RFX1 Antibody; AI047719; AI385641; EF-C; EFC; Enhancer factor C; MHC class II regulatory factor RFX; MHC class II regulatory factor RFX1; Regulatory factor X 1; Regulatory factor X; 1 (influences HLA class II expression); Regulatory factor X1; RFX; RFX-1; Rfx1; RFX1_HUMAN; Trans-acting regulatory factor 1; Transcription factor RFX1; anti-RFX1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: RFX1 Antibody detects endogenous levels of RFX1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-RFX1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human RFX1.
• Conjugation: Unconjugated
• Similarity: Belongs to the RFX family.
• Subunit Structure: Homodimer; binds DNA as a homodimer. Heterodimer; heterodimerizes with RFX2 and RFX3.
• Function: Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-RFX1 antibody

Nucleus; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 238859557
• NCBI GeneID: 5989
• NCBI Accession #: NP_002909
• NCBI GenBank Nucleotide #: NM_002918.4
• UniProt Accession #: P22670
• Molecular Weight: Predicted: 108 kDa; Observed: 125 kDa
• NCBI Official Full Name: MHC class II regulatory factor RFX1
• NCBI Official Synonym Full Names: regulatory factor X1
• NCBI Official Symbol: RFX1
• NCBI Official Synonym Symbols: EFC; RFX
• NCBI Protein Information: MHC class II regulatory factor RFX1
• UniProt Protein Name: MHC class II regulatory factor RFX1
• Protein Family: RFX-like DNA-binding protein
• UniProt Gene Name: RFX1
• UniProt Synonym Gene Names: EF-C; RFX
• UniProt Entry Name: RFX1_HUMAN

NCBI Description

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. [provided by RefSeq, Jul 2008]

Uniprot Description

RFX1: Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. Belongs to the RFX family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus

Molecular Function: protein binding; RNA polymerase II transcription factor activity, enhancer binding

Biological Process: immune response; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent