Rabbit anti-Human, Mouse KIRREL2 Polyclonal Antibody | anti-KIRREL2 antibody
KIRREL2 Antibody
Gene Names
KIRREL2; NLG1; NEPH3; FILTRIN
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
KIRREL2; Polyclonal Antibody; KIRREL2 Antibody; FILTRIN; Kin of IRRE like 2 (Drosophila); Kin of IRRE-like protein 2; Kin of irregular chiasm like 2; Kin of irregular chiasm-like protein 2; KIRR2_HUMAN; NEPH3; Nephrin like 3; nephrin-like gene 1; Nephrin-like protein 3; NLG1; anti-KIRREL2 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
KIRREL2 Antibody detects endogenous levels of KIRREL2.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-KIRREL2 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human KIRREL2.
Conjugation
Unconjugated
Similarity
Belongs to the immunoglobulin superfamily.
Post Translational Modifications
N-glycosylated.The extracellular domain is cleaved leading to the generation of a soluble fragment and a membrane-bound C-terminal fragment, which is further cleaved by gamma-secretase.
Subunit Structure
Homodimer. Interacts with NPHS2/podocin (via the C-terminus). Interacts with NPHS1 (via the Ig-like domains). Interacts with FYN.
Tissue Specificity
Highly expressed in beta-cells of the pancreatic islets.
Function
May regulate basal insulin secretion.
Note
Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta-catenin.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-KIRREL2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Predicted: 64; 70; 78 kDa
Observed: 70 kDa
Observed: 70 kDa
NCBI Official Full Name
kin of IRRE-like protein 2 isoform c
NCBI Official Synonym Full Names
kin of IRRE like 2 (Drosophila)
NCBI Official Symbol
KIRREL2
NCBI Official Synonym Symbols
NLG1; NEPH3; FILTRIN
NCBI Protein Information
kin of IRRE-like protein 2; nephrin-like gene 1; nephrin-like protein 3; kin of irregular chiasm-like protein 2
UniProt Protein Name
Kin of IRRE-like protein 2
Protein Family
UniProt Gene Name
KIRREL2
UniProt Synonym Gene Names
NEPH3
UniProt Entry Name
KIRR2_HUMAN
Uniprot Description
KIRREL2: Belongs to the immunoglobulin superfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.12
Cellular Component: plasma membrane; integral to membrane
Biological Process: cell-cell adhesion; negative regulation of protein amino acid phosphorylation; cell adhesion
Research Articles on KIRREL2
Similar Products
Product Notes
The KIRREL2 kirrel2 (Catalog #AAA9631149) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KIRREL2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's KIRREL2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the KIRREL2 kirrel2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KIRREL2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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