Rabbit PHACTR1 Polyclonal Antibody | anti-PHACTR1 antibody
PHACTR1 Antibody
Gene Names
PHACTR1; RPEL; RPEL1; dJ257A7.2
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
PHACTR1; Polyclonal Antibody; PHACTR1 Antibody; 9630030F18Rik; dJ257A7.2; KIAA1733; MGC112561; MGC126575; MGC126577; Phosphatase and actin regulator 1; RPEL; RPEL repeat containing 1; RPEL1; anti-PHACTR1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
PHACTR1 Antibody detects endogenous levels of PHACTR1.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-PHACTR1 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human PHACTR1.
Conjugation
Unconjugated
Similarity
Binds three actin monomers via the three C-terminal RPEL repeats. Belongs to the phosphatase and actin regulator family.
Subunit Structure
Interacts (via RPEL repeats) with ACTA1 and PPP1CA; ACTA1 and PPP1CA compete for the same binding site.
Tissue Specificity
Detected in umbilical vein endothelial cells.
Function
Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity).
Note
Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity).
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-PHACTR1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
66,308 Da
NCBI Official Full Name
phosphatase and actin regulator 1
NCBI Official Synonym Full Names
phosphatase and actin regulator 1
NCBI Official Symbol
PHACTR1
NCBI Official Synonym Symbols
RPEL; RPEL1; dJ257A7.2
NCBI Protein Information
phosphatase and actin regulator 1; RPEL repeat containing 1
UniProt Protein Name
Phosphatase and actin regulator 1
Protein Family
UniProt Gene Name
PHACTR1
UniProt Synonym Gene Names
KIAA1733; RPEL1
UniProt Entry Name
PHAR1_HUMAN
Uniprot Description
PHACTR1: Belongs to the phosphatase and actin regulator family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 6p24.1
Cellular Component: synapse; cell junction; cytosol; nucleus
Molecular Function: protein phosphatase type 1 regulator activity; protein phosphatase inhibitor activity; actin binding; protein phosphatase 1 binding
Biological Process: actomyosin structure organization and biogenesis; negative regulation of catalytic activity; actin cytoskeleton reorganization; stress fiber formation; cell motility involved in cell locomotion
Research Articles on PHACTR1
Similar Products
Product Notes
The PHACTR1 phactr1 (Catalog #AAA9630784) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PHACTR1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PHACTR1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the PHACTR1 phactr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PHACTR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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