Rabbit anti-Human SPIRE2 Polyclonal Antibody | anti-SPIRE2 antibody
SPIRE2 Antibody
Gene Names
SPIRE2; Spir-2
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
SPIRE2; Polyclonal Antibody; SPIRE2 Antibody; MGC117166; Protein spire homolog 2; Spir-2; SPIR2_HUMAN; Spire homolog 2 (Drosophila); anti-SPIRE2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
SPIRE2 Antibody detects endogenous levels of SPIRE2.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-SPIRE2 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human SPIRE2.
Conjugation
Unconjugated
Similarity
Binds to actin monomers via the WH2 domain. The Spir-box targets binding to intracellular membrane structures. Belongs to the spire family.
Function
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage.
Note
Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-SPIRE2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
65,375 Da
NCBI Official Full Name
protein spire homolog 2
NCBI Official Synonym Full Names
spire-type actin nucleation factor 2
NCBI Official Symbol
SPIRE2
NCBI Official Synonym Symbols
Spir-2
NCBI Protein Information
protein spire homolog 2; spire actin nucleation factor 2; spire family actin nucleation factor 2
UniProt Protein Name
Protein spire homolog 2
Protein Family
UniProt Gene Name
SPIRE2
UniProt Synonym Gene Names
KIAA1832; SPIR2; Spir-2
UniProt Entry Name
SPIR2_HUMAN
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Product Notes
The SPIRE2 spire2 (Catalog #AAA9630695) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SPIRE2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SPIRE2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the SPIRE2 spire2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPIRE2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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