Rabbit HSD17B7 Polyclonal Antibody | anti-HSD17B7 antibody
HSD17B7 Antibody
NCBI and Uniprot Product Information
NCBI Description
HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]
Uniprot Description
Function: Responsible for the reduction of the keto group on the C-3 of sterols. Ref.11
Catalytic activity: A 3-beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH.17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.
Pathway: Steroid biosynthesis; estrogen biosynthesis.Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.
Subcellular location: Cell membrane; Single-pass membrane protein.
Tissue specificity: Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells.
Post-translational modification: Phosphorylated.
Sequence similarities: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.
Research Articles on HSD17B7
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Product Notes
The HSD17B7 hsd17b7 (Catalog #AAA9630317) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HSD17B7 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HSD17B7 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the HSD17B7 hsd17b7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HSD17B7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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