Rabbit anti-Human, Mouse SCUBE1 Polyclonal Antibody | anti-SCUBE1 antibody

SCUBE1 Antibody

Cat. Num. AAA9630246

• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: SCUBE1; Polyclonal Antibody; SCUBE1 Antibody; SCUB1_HUMAN; SCUBE 1; Signal peptide; CUB and EGF-like domain-containing protein 1; CUB domain; EGF like 1; anti-SCUBE1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: SCUBE1 Antibody detects endogenous levels of SCUBE1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-SCUBE1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human SCUBE1.
• Conjugation: Unconjugated
• Post Translational Modifications: N-glycosylated.Could be proteolytically cleaved to release a smaller active fragment.
• Subunit Structure: Forms homooligomers and heterooligomers with SCUBE2 and SCUBE3.
• Tissue Specificity: Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized with the subendothelial matrices in atherosclerotic plaques.
• Function: Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-SCUBE1 antibody

Secreted; Cell membrane; Peripheral membrane protein; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 120587029
• NCBI GeneID: 80274
• NCBI Accession #: NP_766638
• NCBI GenBank Nucleotide #: NM_173050.3
• UniProt Accession #: Q8IWY4; Q5R336
• Molecular Weight: 107,910 Da
• NCBI Official Full Name: signal peptide, CUB and EGF-like domain-containing protein 1
• NCBI Official Synonym Full Names: signal peptide, CUB domain, EGF-like 1
• NCBI Official Symbol: SCUBE1
• NCBI Protein Information: signal peptide, CUB and EGF-like domain-containing protein 1; signal peptide-CUB domain-EGF-related 1
• UniProt Protein Name: Signal peptide, CUB and EGF-like domain-containing protein 1
• Protein Family: Signal peptide, CUB and EGF-like domain-containing protein
• UniProt Gene Name: SCUBE1
• UniProt Entry Name: SCUB1_HUMAN

NCBI Description

This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]

Uniprot Description

SCUBE1: Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.

Chromosomal Location of Human Ortholog: 22q13

Cellular Component: extrinsic to plasma membrane; extracellular space; cell surface; external side of plasma membrane

Molecular Function: identical protein binding; protein heterodimerization activity; calcium ion binding

Biological Process: adult heart development; endothelial cell differentiation; blood coagulation; inflammatory response; protein homooligomerization; post-embryonic development