Rabbit TONSL Polyclonal Antibody | anti-TONSL antibody
TONSL Antibody
Gene Names
TONSL; IKBR; NFKBIL2
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
TONSL; Polyclonal Antibody; TONSL Antibody; I kappa B related protein; I-kappa-B-related protein; IkappaBR; IKBR; Inhibitor of kappa B related protein; Inhibitor of kappa B-related protein; MMS22L-interacting protein; NFBIL2/TONSL; NF kappa B inhibitor like protein 2; NF-kappa-B inhibitor-like protein 2; NFBIL2; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like protein 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2; Protein IkappaBR; Tonsl; TONSL_HUMAN; Tonsoku-like protein; tonsoku-like; DNA repair protein; anti-TONSL antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
TONSL Antibody detects endogenous levels of TONSL.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-TONSL antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human TONSL.
Conjugation
Unconjugated
Similarity
The ANK repeats mediate the interaction with the MCM complex and histones, while the LRR repeats mediate the interaction with MMS22L. Belongs to the Tonsoku family.
Subunit Structure
Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2. Interacts with the MCM complex, the FACT complex and the RPA complex. Binds histones.
Tissue Specificity
Expressed in heart, skeletal muscle and tracheal epithelial cells.
Function
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.
Note
Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
150,894 Da
NCBI Official Full Name
tonsoku-like protein
NCBI Official Synonym Full Names
tonsoku-like, DNA repair protein
NCBI Official Symbol
TONSL
NCBI Official Synonym Symbols
IKBR; NFKBIL2
NCBI Protein Information
tonsoku-like protein; I-kappa-B-related protein; NF-kappa-B inhibitor-like protein 2; ikappaBR; inhibitor of kappa B-related protein; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2
UniProt Protein Name
Tonsoku-like protein
UniProt Gene Name
TONSL
UniProt Synonym Gene Names
IKBR; NFKBIL2; I-kappa-B-related protein; IkappaBR
UniProt Entry Name
TONSL_HUMAN
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Product Notes
The TONSL tonsl (Catalog #AAA9630194) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TONSL Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TONSL can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the TONSL tonsl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TONSL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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