Rabbit anti-Human, Mouse PLXNB1 Polyclonal Antibody | anti-PLXNB1 antibody
PLXNB1 Antibody
Gene Names
PLXNB1; SEP; PLXN5; PLEXIN-B1
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
PLXNB1; Polyclonal Antibody; PLXNB1 Antibody; KIAA0407; Plexin 5; Plexin B1; PLXN5; Semaphorin receptor; Semaphorin receptor SEP; SEP; anti-PLXNB1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
PLXNB1 Antibody detects endogenous levels of PLXNB1.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-PLXNB1 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human PLXNB1.
Conjugation
Unconjugated
Similarity
Belongs to the plexin family.
Post Translational Modifications
Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.
Subunit Structure
Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Interacts with PLXNA1 (By similarity). Interacts with ARHGEF11 and ARHGEF12. Interacts with ERBB2. Interacts with MET. Interacts with MST1R. Interacts with RRAS. Interacts with RHOD. Interacts with RND1. Interacts with NRP1 and NRP2.
Tissue Specificity
Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.
Function
Receptor for SEMA4D. Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-PLXNB1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
214,411 Da
NCBI Official Full Name
PLXNB1 protein
NCBI Official Synonym Full Names
plexin B1
NCBI Official Symbol
PLXNB1
NCBI Official Synonym Symbols
SEP; PLXN5; PLEXIN-B1
NCBI Protein Information
plexin-B1
UniProt Protein Name
Plexin-B1
Protein Family
UniProt Gene Name
PLXNB1
UniProt Synonym Gene Names
KIAA0407; PLXN5; SEP
Uniprot Description
Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
Research Articles on PLXNB1
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Product Notes
The PLXNB1 plxnb1 (Catalog #AAA9630084) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PLXNB1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PLXNB1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the PLXNB1 plxnb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLXNB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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