Rabbit KCNAB1 Polyclonal Antibody | anti-KCNAB1 antibody

KCNAB1 Antibody

Cat. Num. AAA9629805

• Gene Names: KCNAB1; hKvb3; AKR6A3; KCNA1B; Kvb1.3; hKvBeta3; KV-BETA-1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: KCNAB1; Polyclonal Antibody; KCNAB1 Antibody; hKvb3; hKvBeta3; K(+) channel subunit beta-1; KCAB1_HUMAN; KCNA1B; Kv-beta-1; Kvb1.3; Voltage-gated potassium channel beta-1 subunit; Voltage-gated potassium channel subunit beta-1; anti-KCNAB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: KCNAB1 Antibody detects endogenous levels of KCNAB1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-KCNAB1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human KCNAB1.
• Conjugation: Unconjugated
• Similarity: The N-terminal domain of the beta subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore. Belongs to the shaker potassium channel beta subunit family.
• Subunit Structure: Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (Probable). Identified in potassium channel complexes containing KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNAB1 and KCNAB2 (By similarity). Interacts with KCNA1 (By similarity). Interacts with the dimer formed by GNB1 and GNG2; this enhances KCNA1 binding (By similarity). Interacts with KCNA4. Interacts with KCNA5. Interacts with KCNB2 (By similarity). Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1; interaction with LGI1 inhibits down-regulation of KCNA1 channel activity (By similarity).
• Tissue Specificity: In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.
• Function: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Promotes the closure of KCNA1, KCNA2 and KCNA5 channels. Accelerates KCNA4 channel closure. Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4. Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1. Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity. Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).
• Note: Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-KCNAB1 antibody

Cytoplasm; Membrane; Peripheral membrane protein; Cytoplasmic side; Cell membrane; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 27436962
• NCBI GeneID: 7881
• NCBI Accession #: NP_003462.2
• NCBI GenBank Nucleotide #: NM_003471.3
• UniProt Accession #: Q14722; Q13031; Q13302; Q16547; Q6PI60; Q99869; A8K9H8; A8KAD4; B3KPZ4
• Molecular Weight: 45,492 Da
• NCBI Official Full Name: voltage-gated potassium channel subunit beta-1 isoform 2
• NCBI Official Synonym Full Names: potassium voltage-gated channel, shaker-related subfamily, beta member 1
• NCBI Official Symbol: KCNAB1
• NCBI Official Synonym Symbols: hKvb3; AKR6A3; KCNA1B; Kvb1.3; hKvBeta3; KV-BETA-1
• NCBI Protein Information: voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; potassium channel beta 3 chain; potassium channel beta3 subunit; potassium channel shaker chain beta 1a; potassium voltage-gated channel beta subunit; voltage-gated potassium cha
• UniProt Protein Name: Voltage-gated potassium channel subunit beta-1
• Protein Family: Voltage-gated potassium channel
• UniProt Gene Name: KCNAB1
• UniProt Synonym Gene Names: KCNA1B
• UniProt Entry Name: KCAB1_HUMAN

NCBI Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv-beta1: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1. Belongs to the shaker potassium channel beta subunit family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: extrinsic to internal side of plasma membrane; plasma membrane; cytosol

Molecular Function: voltage-gated potassium channel activity; potassium channel regulator activity; aldo-keto reductase activity

Biological Process: synaptic transmission; learning and/or memory; potassium ion transport