Rabbit Coatomer subunit delta Polyclonal Antibody | anti-ARCN1 antibody

Coatomer subunit delta Antibody

Cat. Num. AAA9629436

• Gene Names: ARCN1; COPD
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: Coatomer subunit delta; Polyclonal Antibody; Coatomer subunit delta Antibody; Archain 1; Archain; Archain vesicle transport protein 1; Arcn1; Coatomer delta subunit; Coatomer protein complex; subunit delta; Coatomer protein delta COP; COPD_HUMAN; Delta coat protein; Delta COP; Delta-coat protein; Delta-COP; anti-ARCN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Coatomer subunit delta Antibody detects endogenous levels of total Coatomer subunit delta.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-ARCN1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
• Subunit Structure: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
• Tissue Specificity: Ubiquitously expressed.
• Function: Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
• Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-ARCN1 antibody

Cytoplasm; Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side; Cytoplasmic vesicle; COPI-coated vesicle membrane; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 40675522
• NCBI GeneID: 372
• UniProt Accession #: P48444; Q52M80; B4E1X2; E9PEU4
• Molecular Weight: 57,210 Da
• NCBI Official Full Name: ARCN1 protein
• NCBI Official Synonym Full Names: archain 1
• NCBI Official Symbol: ARCN1
• NCBI Official Synonym Symbols: COPD
• NCBI Protein Information: coatomer subunit delta; delta-COP; delta-coat protein; coatomer delta subunit; coatomer protein delta-COP; archain vesicle transport protein 1; coatomer protein complex, subunit delta
• UniProt Protein Name: Coatomer subunit delta
• Protein Family: Coatomer
• UniProt Gene Name: ARCN1
• UniProt Synonym Gene Names: COPD; Delta-COP
• UniProt Entry Name: COPD_HUMAN

NCBI Description

This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008]

Uniprot Description

ARCN1: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: Golgi apparatus; clathrin adaptor complex; membrane; intracellular membrane-bound organelle; endoplasmic reticulum; cytoplasm; COPI vesicle coat; cytosol

Biological Process: cerebellar Purkinje cell layer maturation; intracellular protein transport; COPI coating of Golgi vesicle; pigmentation; adult locomotory behavior; retrograde vesicle-mediated transport, Golgi to ER