Rabbit SND1 Polyclonal Antibody | anti-SND1 antibody

SND1 Antibody

Cat. Num. AAA9629098

• Gene Names: SND1; p100; TDRD11
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: SND1; Polyclonal Antibody; SND1 Antibody; 100 kDa coactivator; EBNA 2 co activator (100kD); EBNA2 coactivator p100; p100; p100 co-activator; p100 coactivator; p100 EBNA2 co activator; SND 1; Snd1; SND1_HUMAN; Staphylococcal nuclease and tudor domain containing 1; Staphylococcal nuclease domain containing 1; Staphylococcal nuclease domain containing protein 1; Staphylococcal nuclease domain-containing protein 1; TDRD11; TRD 11; TRD11; Tudor domain containing protein 11; Tudor domain-containing protein 11; anti-SND1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: SND1 Antibody detects endogenous levels of total SND1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-SND1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Post Translational Modifications: Phosphorylated by PIM1 in vitro.
• Subunit Structure: Forms a ternary complex with STAT6 and POLR2A. Associates with the RNA-induced silencing complex (RISC). Interacts with the RISC components AGO2, FMR1 and TNRC6A. Interacts with GTF2E1 and GTF2E2. Interacts with PIM1. Interacts with STAT5 (By similarity). Interacts with SYT11 (via C2 2 domain); the interaction with SYT11 is direct (By similarity).(Microbial infection) Interacts with EAV NSP1. Binds to acidic transactivation domain of EBNA2.
• Tissue Specificity: Ubiquitously expressed.
• Function: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5 (By similarity).(Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).
• Note: In IL-4 stimulated cells colocalizes with STAT6 in the nucleus (PubMed:12234934). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-SND1 antibody

Cytoplasm; Nucleus; Melanosome; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 77404397
• NCBI GeneID: 27044
• NCBI Accession #: NP_055205.2
• NCBI GenBank Nucleotide #: NM_014390.2
• UniProt Accession #: Q7KZF4; Q13122; Q96AG0
• Molecular Weight: 101,997 Da
• NCBI Official Full Name: staphylococcal nuclease domain-containing protein 1
• NCBI Official Synonym Full Names: staphylococcal nuclease and tudor domain containing 1
• NCBI Official Symbol: SND1
• NCBI Official Synonym Symbols: p100; TDRD11
• NCBI Protein Information: staphylococcal nuclease domain-containing protein 1; SND1-BRAF fusion; p100 co-activator; 100 kDa coactivator; EBNA2 coactivator p100; p100 EBNA2 co-activator; EBNA-2 co-activator (100kD); tudor domain-containing protein 11; staphylococcal nuclease domain
• UniProt Protein Name: Staphylococcal nuclease domain-containing protein 1
• Protein Family: Staphylococcal nuclease domain-containing protein
• UniProt Gene Name: SND1
• UniProt Synonym Gene Names: TDRD11
• UniProt Entry Name: SND1_HUMAN

Uniprot Description

SND1: a transcriptional coactivator for STAT6. May function as a bridging factor between STAT6 and the basal transcription machinery.

Protein type: RNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 7q31.3

Cellular Component: membrane; mitochondrion; cytoplasm; melanosome; nucleus

Molecular Function: protein binding; nuclease activity; transcription cofactor activity

Biological Process: osteoblast differentiation; regulation of transcription, DNA-dependent; viral reproduction; transcription, DNA-dependent; RNA-mediated gene silencing