PTGER2 blocking peptide

PTGER2 Blocking Peptide

Cat. Num. AAA9625309

• Gene Names: PTGER2; EP2
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: PTGER2; PTGER2 Blocking Peptide; EP2; PE2R2_HUMAN; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; Prostaglandin E receptor 2 EP2 subtype; Prostaglandin E receptor 2 subtype EP2 53kDa; Prostaglandin E receptor 2 subtype EP2; Prostaglandin E2 receptor; Prostaglandin E2 receptor EP2 subtype; Prostanoid EP2 receptor; Ptger2; PTGER2 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for PTGER2 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PTGER2 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 31881630
• NCBI GeneID: 5732
• NCBI Accession #: NP_000947.2
• NCBI GenBank Nucleotide #: NM_000956.3
• UniProt Accession #: P43116; Q52LG8; D3DSC0
• Molecular Weight: 39,761 Da
• NCBI Official Full Name: prostaglandin E2 receptor EP2 subtype
• NCBI Official Synonym Full Names: prostaglandin E receptor 2 (subtype EP2), 53kDa
• NCBI Official Symbol: PTGER2
• NCBI Official Synonym Symbols: EP2
• NCBI Protein Information: prostaglandin E2 receptor EP2 subtype; prostanoid EP2 receptor; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype
• UniProt Protein Name: Prostaglandin E2 receptor EP2 subtype
• Protein Family: Prostaglandin E2 receptor
• UniProt Gene Name: PTGER2
• UniProt Synonym Gene Names: PGE receptor EP2 subtype
• UniProt Entry Name: PE2R2_HUMAN

NCBI Description

This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

Uniprot Description

PTGER2: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 14q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: prostaglandin E receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; response to lipopolysaccharide; G-protein signaling, adenylate cyclase activating pathway; regulation of cell proliferation

Disease: Asthma, Nasal Polyps, And Aspirin Intolerance