DSE blocking peptide

DSE Blocking Peptide

Cat. Num. AAA9621665

• Gene Names: DSE; DSEP; DSEPI; SART2; EDSMC2; SART-2
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: DSE; DSE Blocking Peptide; DSE blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for DSE blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DSE blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 124494231
• NCBI GeneID: 29940
• NCBI Accession #: NP_001074445.1
• NCBI GenBank Nucleotide #: NP_001074445.1
• UniProt Accession #: Q9UL01; Q5R3K6
• Molecular Weight: 109,773 Da
• NCBI Official Full Name: dermatan-sulfate epimerase
• NCBI Official Synonym Full Names: dermatan sulfate epimerase
• NCBI Official Symbol: DSE
• NCBI Official Synonym Symbols: DSEP; DSEPI; SART2; EDSMC2; SART-2
• NCBI Protein Information: dermatan-sulfate epimerase; DS epimerase; chondroitin-glucuronate 5-epimerase; squamous cell carcinoma antigen recognized by T-cells 2
• UniProt Protein Name: Dermatan-sulfate epimerase
• Protein Family: Dermatan-sulfate epimerase
• UniProt Gene Name: DSE
• UniProt Synonym Gene Names: SART2; DS epimerase; SART-2
• UniProt Entry Name: DSE_HUMAN

NCBI Description

The protein encoded by this gene is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is localized to the endoplasmic reticulum. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SART2: Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Belongs to the dermatan-sulfate isomerase family.

Protein type: Isomerase; Endoplasmic reticulum; Membrane protein, integral; EC 5.1.3.19; Glycan Metabolism - chondroitin sulfate biosynthesis; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q22

Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum; integral to membrane

Molecular Function: chondroitin-glucuronate 5-epimerase activity

Biological Process: chondroitin sulfate metabolic process; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; heparan sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; pathogenesis; dermatan sulfate biosynthetic process

Disease: Ehlers-danlos Syndrome, Musculocontractural Type 2