KIF1B blocking peptide

Phospho-KIF1B (Ser1487) Blocking Peptide

Cat. Num. AAA9615241

• Gene Names: KIF1B; KLP; CMT2; CMT2A; CMT2A1; HMSNII; NBLST1; FLJ23699; KIAA0591; KIAA1448; MGC134844
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: KIF1B; Phospho-KIF1B (Ser1487) Blocking Peptide; Charcot Marie Tooth neuropathy 2A; CMT 2; CMT 2A; CMT 2A1; CMT2 A; CMT2 A1; CMT2; CMT2A 1; CMT2A; CMT2A1; D4Mil1e; HMSN II; HMSNII; hereditary motor sensory neuropathy II; KIF 1B; KIF1 B; KIF1B p130; KIF1B p204; KIF1Bp130; KIF1Bp204; kinesin family member 1B; Kinesin like protein KIF1B; Klp; KIF1B blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for KIF1B blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for KIF1B blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 41393563
• NCBI GeneID: 23095
• NCBI Accession #: NP_055889.2
• NCBI GenBank Nucleotide #: NM_015074.3
• UniProt Accession #: O60333; Q4VXC3; Q4VXC4; Q4VXC5; Q4VXC6; Q96Q94; Q9BV80; Q9P280; A6NFS8; A6NKQ4
• Molecular Weight: 204,476 Da
• NCBI Official Full Name: kinesin-like protein KIF1B isoform b
• NCBI Official Synonym Full Names: kinesin family member 1B
• NCBI Official Symbol: KIF1B
• NCBI Official Synonym Symbols: KLP; CMT2; CMT2A; CMT2A1; HMSNII; NBLST1; FLJ23699; KIAA0591; KIAA1448; MGC134844
• NCBI Protein Information: kinesin-like protein KIF1B; OTTHUMP00000001772; OTTHUMP00000001773; OTTHUMP00000001774; OTTHUMP00000001775; OTTHUMP00000001776; kinesin superfamily protein KIF1B
• UniProt Protein Name: Kinesin-like protein KIF1B
• Protein Family: Kinesin-like protein
• UniProt Gene Name: KIF1B
• UniProt Synonym Gene Names: KIAA0591; KIAA1448; Klp
• UniProt Entry Name: KIF1B_HUMAN

Uniprot Description

KIF1B: a member of the kinesin motor protein family. Motor for anterograde transport of mitochondria. May play a role in synaptic vesicle transport. Has a microtubule plus end-directed motility. Aberrant expression seen in neuroblastoma. Mutated in Charcot-Marie-Tooth disease.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 1p36.2

Cellular Component: microtubule; kinesin complex; neuron projection; microtubule associated complex; cytoplasmic vesicle membrane; mitochondrion; cytoplasmic vesicle

Molecular Function: protein binding; kinesin binding; plus-end-directed microtubule motor activity; microtubule binding; ATPase activity; microtubule motor activity; ATP binding

Biological Process: vesicle-mediated transport; apoptosis; metabolic process; neuromuscular synaptic transmission; nerve-nerve synaptic transmission; cytoskeleton-dependent intracellular transport; anterograde axon cargo transport; microtubule-based movement; mitochondrion transport along microtubule

Disease: Charcot-marie-tooth Disease, Axonal, Type 2a1; Neuroblastoma, Susceptibility To; Pheochromocytoma