Western Blot (WB)
(Western blot analysis of extracts from K-562 cells, using NOSTRIN Antibody. The lane on the left was treated with blocking peptide.)
Rabbit NOSTRIN Polyclonal Antibody | anti-NOSTRIN antibody
NOSTRIN Antibody
Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Western Blot (WB)
(Western blot analysis of extracts from K-562 cells, using NOSTRIN Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from K-562 cells, using NOSTRIN Antibody. The lane on the left was treated with blocking peptide.)
Subunit Structure: Homotrimer. Interacts with DAB2 (By similarity). Interacts with NOS3, DNM2, WASL and CAV1.
Similarity: The SH3 domain mediates interaction with NOS3, DNM2 and WASL. The F-BAR domain is necessary for membrane targeting.
NCBI and Uniprot Product Information
Predicted: 58 kDa
NCBI Description
Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]
Uniprot Description
NOSTRIN: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component: cytoskeleton; plasma membrane; nucleus
Molecular Function: protein binding; DNA binding
Biological Process: endocytosis; regulation of nitric-oxide synthase activity; signal transduction; negative regulation of transcription, DNA-dependent; nitric oxide metabolic process
Research Articles on NOSTRIN
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Product Notes
The NOSTRIN nostrin (Catalog #AAA9611425) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NOSTRIN Antibody reacts with Human, Mouse, Rat Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's NOSTRIN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the NOSTRIN nostrin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NOSTRIN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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