C-X-C chemokine receptor type 4 (CXCR4) Recombinant Protein | CXCR4 recombinant protein
Recombinant Cat C-X-C chemokine receptor type 4 (CXCR4)
NCBI and Uniprot Product Information
Uniprot Description
Function: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival
By similarity. Acts as a coreceptor (CD4 being the primary receptor) for FIV isolates. Promotes Env-mediated fusion of the virus.
Subunit structure: Monomer
By similarity. Can form dimers
By similarity. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin; the interaction enhances intracellular calcium ions and reduces cellular cAMP levels
By similarity.
Subcellular location: Cell membrane; Multi-pass membrane protein
By similarity. Note: In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated
By similarity.
Post-translational modification: Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-325 and Ser-326 leads to recruitment of ITCH, ubiquitination and protein degradation
By similarity.Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S
By similarity.Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization
By similarity.O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity
By similarity.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Research Articles on CXCR4
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Product Notes
The CXCR4 cxcr4 (Catalog #AAA961043) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-353. The amino acid sequence is listed below: MDGFRIYPSD NYTEDDLGSG DYDSMKEPCF REENAHFNRI FLPTVYSIIF LTGIVGNGLV ILVMGYQKKL RSMTDKYRLH LSVADLLFVL TLPFWAVDAV ANWYFGKFLC KAVHVIYTVN LYSSVLILAF ISLDRYLAIV HATNSQRPRK LLAEKVVYVG VWIPALLLTI PDFIFANVRE ADGRYICDRF YPSDSWLVVF QFQHIMVGLI LPGIVILSCY CIIISKLSHS KGYQKRKALK TTVILILAFF ACWLPYYIGI SIDSFILLEI IKQGCEFEST VHKWISITEA LAFFHCCLNP ILYAFLGAKF KTSAQHALTS VSRGSSLKIL SKGKRGGHSS VSTESESSSF HSS. It is sometimes possible for the material contained within the vial of "C-X-C chemokine receptor type 4 (CXCR4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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