Western Blot (WB)
(Western blot analysis of extracts from HepG2, using DRD2 Antibody.)
Rabbit anti-Human, Rat DRD2 Polyclonal Antibody | anti-DRD2 antibody
DRD2 Antibody
Gene Names
DRD2; D2R; D2DR
Reactivity
Human, Rat
Applications
Western Blot, ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Synonyms
DRD2; Polyclonal Antibody; DRD2 Antibody; D(2) dopamine receptor; D2 dopamine receptor; D2DR; D2R; Dopamine D2 receptor; Dopamine receptor D2; DRD 2; DRD2_HUMAN; anti-DRD2 antibody
Host
Rabbit
Reactivity
Human, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
DRD2 antibody detects endogenous levels of total DRD2
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
443
Applicable Applications for anti-DRD2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:1000-3000
Immunogen
A synthesized peptide derived from human DRD2
Subcellular Location
Cell Membrane
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Rabbit, Dog
Similarity
Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%)
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of extracts from HepG2, using DRD2 Antibody.)
Western Blot (WB)
(Western blot analysis of extracts from HepG2, using DRD2 Antibody.)
Western Blot (WB)
(Western blot analysis of DRD2 using HT-29 whole cell lysates)
Western Blot (WB)
(Western blot analysis of DRD2 using HT-29 whole cell lysates)
Related Product Information for anti-DRD2 antibody
Function: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
Subunit Structure: Forms homo-and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2. Interacts with ARRB2 (By similarity). Interacts with KCNA2 (By similarity). Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation. Interacts with HTR2A.
Similarity: Belongs to the G-protein coupled receptor 1 family.
Subunit Structure: Forms homo-and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2. Interacts with ARRB2 (By similarity). Interacts with KCNA2 (By similarity). Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation. Interacts with HTR2A.
Similarity: Belongs to the G-protein coupled receptor 1 family.
References
Liu Y, Geng L, Zhang J, Wang J, Zhang Q, Duan D, Zhang Q; Journal: Mar Drugs. Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Observed: 51 kDa
Predicted: 51 kDa
Predicted: 51 kDa
NCBI Official Full Name
D(2) dopamine receptor isoform long
NCBI Official Synonym Full Names
dopamine receptor D2
NCBI Official Symbol
DRD2
NCBI Official Synonym Symbols
D2R; D2DR
NCBI Protein Information
D(2) dopamine receptor
UniProt Protein Name
D(2) dopamine receptor
Protein Family
UniProt Gene Name
DRD2
NCBI Description
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
Uniprot Description
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
Research Articles on DRD2
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Product Notes
The DRD2 drd2 (Catalog #AAA9603069) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DRD2 Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DRD2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:1000-3000. Researchers should empirically determine the suitability of the DRD2 drd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DRD2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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