Rhodopsin (RHO) Recombinant Protein | RHO recombinant protein
Recombinant Dog Rhodopsin (RHO)
NCBI and Uniprot Product Information
Uniprot Description
Function: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.
Subunit structure: Homodimer
By similarity.
Subcellular location: Membrane; Multi-pass membrane protein. Note: Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia
By similarity.
Tissue specificity: Rod shaped photoreceptor cells which mediates vision in dim light.
Post-translational modification: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.Contains one covalently linked retinal chromophore
By similarity.
Involvement in disease: Note=Defects in RHO are a cause of autosomal dominant retinitis pigmentosa (ADRP). The phenotypic features shared by dog and man include a dramatically slowed time course of recovery of rod photoreceptor function after light exposure and a distinctive topographic pattern to the retinal degeneration. This disease was identified in the English mastiff breed. Ref.3
Sequence similarities: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Biophysicochemical propertiesAbsorption:Abs(max)=495 nm
Research Articles on RHO
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Product Notes
The RHO rho (Catalog #AAA958245) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-348. The amino acid sequence is listed below: MNGTEGPNFY VPFSNKTGVV RSPFEYPQYY LAEPWQFSML AAYMFLLIVL GFPINFLTLY VTVQHKKLRT PLNYILLNLA VADLFMVFGG FTTTLYTSLH GYFVFGPTGC NVEGFFATLG GEIALWSLVV LAIERYVVVC KPMSNFRFGE NHAIMGVAFT WVMALACAAP PLAGWSRYIP EGMQCSCGID YYTLKPEINN ESFVIYMFVV HFAIPMIVIF FCYGQLVFTV KEAAAQQQES ATTQKAEKEV TRMVIIMVIA FLICWVPYAS VAFYIFTHQG SDFGPIFMTL PAFFAKSSSI YNPVIYIMMN KQFRNCMITT LCCGKNPLGD DEASASASKT ETSQVAPA. It is sometimes possible for the material contained within the vial of "Rhodopsin (RHO), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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