PAK3 elisa kit

Phospho-PAK3 (Ser154) Colorimetric Cell-Based ELISA Kit

Cat. Num. AAA9501639

• Gene Names: PAK3; ARA; bPAK; MRX30; MRX47; OPHN3; PAK-3; PAK3beta; beta-PAK
• Reactivity: Human, Mouse, Rat
• Synonyms: PAK3; Phospho-PAK3 (Ser154) Colorimetric Cell-Based ELISA Kit; p21-activated kinase 3; PAK-3; Beta-PAK; CDC42/RAC effector kinase PAK-B; PAK3 elisa kit

• Reactivity: Human, Mouse, Rat
• Form/Format: Two 96-Well Plates
• Sequence Length: 544

• Samples: Researchers plate their cell line of choice
• Assay Type: Phospho Cell-Based ELISA
• Sensitivity: >=5000 cells/well
• Reactivity Note: Human: S154, Mouse: S154, Rat: S139
• Detection Method: Colorimetric 450 nm
• Preparation and Storage: Store at 4 degree C.

Product Categories/Family for PAK3 elisa kit

Cell Based ELISA Kit

NCBI and Uniprot Product Information

• NCBI GI #: 189491751
• NCBI GeneID: 5063
• NCBI Accession #: NP_001121638.1
• NCBI GenBank Nucleotide #: NM_001128166.2
• UniProt Accession #: O75914; Q5JWX1; Q5JWX2; Q7Z2D6; Q7Z2E4; Q7Z3Z8; Q8WWK5; Q8WX23; A8K389; B1GX77; B1GX78; B1GX79
• Molecular Weight: 62310
• NCBI Official Full Name: serine/threonine-protein kinase PAK 3 isoform a
• NCBI Official Synonym Full Names: p21 (RAC1) activated kinase 3
• NCBI Official Symbol: PAK3
• NCBI Official Synonym Symbols: ARA; bPAK; MRX30; MRX47; OPHN3; PAK-3; PAK3beta; beta-PAK
• NCBI Protein Information: serine/threonine-protein kinase PAK 3
• UniProt Protein Name: Serine/threonine-protein kinase PAK 3
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: PAK3
• UniProt Synonym Gene Names: OPHN3; PAK-3

NCBI Description

The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]

Uniprot Description

PAK3: a protein kinase of the STE20 family that regulates synapse formation and plasticity in the hippocampus. May be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Forms an activated complex with GTP-bound P21, CDC2 and RAC1 proteins. Missense and truncation mutations linked to nonsyndromic mental retardation type 30 (MRX30). Two alternatively spliced human isoforms have been reported.

Protein type: EC 2.7.11.1; Kinase, protein; PAKA subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family

Chromosomal Location of Human Ortholog: Xq23

Cellular Component: cytoplasm; cytosol; endosome; plasma membrane

Molecular Function: ATP binding; MAP kinase kinase activity; metal ion binding; protein binding; protein serine/threonine kinase activity; Rac GTPase binding; SH3 domain binding

Biological Process: activation of MAPK activity; axonogenesis; cell migration; cellular response to organic cyclic compound; dendrite development; ephrin receptor signaling pathway; MAPK cascade; positive regulation of DNA biosynthetic process; positive regulation of fibroblast migration; positive regulation of neuron apoptotic process; regulation of actin filament polymerization; regulation of apoptosis; regulation of axonogenesis; regulation of mitotic cell cycle; Rho protein signal transduction; stimulatory C-type lectin receptor signaling pathway; stress-activated protein kinase signaling pathway; synapse organization; T cell costimulation; T cell receptor signaling pathway

Disease: Mental Retardation, X-linked 30