GATA1 elisa kit

Phospho-GATA1 (Ser310) Colorimetric Cell-Based ELISA Kit

Cat. Num. AAA9501461

• Gene Names: GATA1; GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1
• Reactivity: Human, Mouse, Rat
• Synonyms: GATA1; Phospho-GATA1 (Ser310) Colorimetric Cell-Based ELISA Kit; Erythroid transcription factor; Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein; ERYF1; GF1; GATA1 elisa kit

• Reactivity: Human, Mouse, Rat
• Form/Format: Two 96-Well Plates
• Sequence Length: 413

• Samples: Researchers plate their cell line of choice
• Assay Type: Phospho Cell-Based ELISA
• Sensitivity: >=5000 cells/well
• Reactivity Note: Human: S310, Mouse: S310, Rat: S310
• Detection Method: Colorimetric 450 nm
• Preparation and Storage: Store at 4 degree C.

Product Categories/Family for GATA1 elisa kit

Cell Based ELISA Kit

NCBI and Uniprot Product Information

• NCBI GI #: 4503925
• NCBI GeneID: 2623
• NCBI Accession #: NP_002040.1
• NCBI GenBank Nucleotide #: NM_002049.3
• UniProt Accession #: P15976; Q96GB8
• Molecular Weight: 42751
• NCBI Official Full Name: erythroid transcription factor
• NCBI Official Synonym Full Names: GATA binding protein 1
• NCBI Official Symbol: GATA1
• NCBI Official Synonym Symbols: GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1
• NCBI Protein Information: erythroid transcription factor
• UniProt Protein Name: Erythroid transcription factor
• Protein Family: GATA transcription factor
• UniProt Gene Name: GATA1
• UniProt Synonym Gene Names: ERYF1; GF1; GATA-1; GF-1

NCBI Description

This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]

Uniprot Description

GATA1: Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. May form homodimers or heterodimers with other isoforms. Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner. Interacts with LMCD1. Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo. Interacts with EP300. Erythrocytes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: nucleoplasm; nucleus; transcription factor complex; transcriptional repressor complex

Molecular Function: chromatin DNA binding; DNA binding; DNA binding transcription factor activity; DNA binding, bending; p53 binding; protein binding; sequence-specific DNA binding; zinc ion binding

Biological Process: basophil differentiation; blood coagulation; cell-cell signaling; embryonic hemopoiesis; eosinophil differentiation; erythrocyte development; erythrocyte differentiation; homeostasis of number of cells within a tissue; in utero embryonic development; male gonad development; megakaryocyte differentiation; negative regulation of apoptosis; negative regulation of bone mineralization; negative regulation of cell proliferation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription regulatory region DNA binding; platelet formation; positive regulation of erythrocyte differentiation; positive regulation of osteoblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of definitive erythrocyte differentiation; regulation of glycoprotein biosynthetic process; regulation of hematopoietic stem cell differentiation; regulation of megakaryocyte differentiation; regulation of primitive erythrocyte differentiation; transcription from RNA polymerase II promoter; transcriptional activation by promoter-enhancer looping

Disease: Anemia, X-linked, With Or Without Neutropenia And/or Platelet Abnormalities; Down Syndrome; Thrombocytopenia With Beta-thalassemia, X-linked; Thrombocytopenia, X-linked, With Or Without Dyserythropoietic Anemia