Synaptotagmin ELISA Kit | SYT elisa kit
Phospho-Synaptotagmin (Ser309) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
Uniprot Description
SYT1: an integral membrane protein of synaptic vesicles thought to serve as a Ca(2+) sensor in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. Binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Protein type: Calcium-binding; Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 12q21.2
Cellular Component: cell junction; clathrin-coated vesicle membrane; clathrin-sculpted monoamine transport vesicle membrane; excitatory synapse; Golgi apparatus; integral to synaptic vesicle membrane; neuron projection; plasma membrane; presynaptic membrane; SNARE complex; synaptic vesicle; synaptic vesicle membrane; terminal bouton
Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; calmodulin binding; clathrin binding; identical protein binding; low-density lipoprotein receptor binding; phosphatidylinositol binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein binding; protein C-terminus binding; protein heterodimerization activity; SNARE binding; syntaxin-1 binding; syntaxin-3 binding
Biological Process: brain development; calcium ion-dependent exocytosis of neurotransmitter; cellular response to calcium ion; detection of calcium ion; fast, calcium ion-dependent exocytosis of neurotransmitter; glutamate secretion; neurotransmitter secretion; positive regulation of calcium ion-dependent exocytosis; positive regulation of dendrite extension; positive regulation of synaptic transmission; positive regulation of vesicle fusion; protein heterooligomerization; protein homooligomerization; regulation of calcium ion-dependent exocytosis; regulation of dopamine secretion; regulation of exocytosis; regulation of synaptic transmission, glutamatergic; synaptic transmission; synaptic vesicle endocytosis; vesicle docking; vesicle fusion
Research Articles on SYT
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Product Notes
The Human, Mouse, Rat SYT syt1 (Catalog #AAA9500994) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500994 ELISA Kit recognizes Human, Mouse, Rat SYT. It is sometimes possible for the material contained within the vial of "Synaptotagmin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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