Human, Mouse CKI-epsilon ELISA Kit | CKI-epsilon elisa kit
CKI-epsilon Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This locus represents naturally occurring readthrough transcription between the neighboring LOC400927 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene) and CSNK1E (casein kinase I isoform epsilon) genes on chromosome 22. The readthrough transcript encodes the same protein as the downstream gene product (casein kinase I isoform epsilon). [provided by RefSeq, Feb 2014]
Uniprot Description
CK1E: an ubiquitous protein kinase of the CK1 family. Together with Dvl-1 and Frat-1 activate the Wnt signaling pathway. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. May play a role in cell cycle progression. Two splice variant isoforms have been described. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CK1-D and/or CK1-E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with SOCS3. Mutations in hamster and Drosophila orthologs have circadian rhythm phenotypes, and the circadian gene period (per) is a substrate in both human and fly. A coding SNP variant in human, which increases CK1 activity, is negatively associated with circadian disorder. LOF mutations and LOH seen in mammary ductal carcinoma.
Protein type: CK1 group; CK1 family; EC 2.7.11.1; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: ATP binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; RNA binding
Biological Process: circadian regulation of gene expression; DNA repair; endocytosis; G2/M transition of mitotic cell cycle; negative regulation of protein binding; peptidyl-serine phosphorylation; positive regulation of non-canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; protein amino acid phosphorylation; regulation of cell shape; regulation of circadian rhythm; regulation of G2/M transition of mitotic cell cycle; rRNA processing; signal transduction; Wnt signaling pathway
Research Articles on CKI-epsilon
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Product Notes
The Human, Mouse CKI-epsilon csnk1e (Catalog #AAA9500760) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500760 ELISA Kit recognizes Human, Mouse CKI-epsilon. It is sometimes possible for the material contained within the vial of "CKI-epsilon, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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