Human, Mouse WWOX ELISA Kit | WWOX elisa kit
WWOX Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Description
WWOX: an enzyme which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). Expressed at high levels in hormonally regulated tissues such as testis, ovary, and prostate. Its SRD domain suggest a role for this gene in steroid metabolism. Shown to be an essential mediator of tumor necrosis factor-alpha-induced apoptosis in the mouse. May play a similar role in the human. May function as a suppressor of tumor growth. Alternative splicing of this gene generates 7 isoforms.
Protein type: Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor
Chromosomal Location of Human Ortholog: 16q23.1-q23.2
Cellular Component: cytoplasm; cytosol; Golgi apparatus; microvillus; mitochondrion; nucleus; plasma membrane; RNA polymerase II transcription factor complex
Molecular Function: coenzyme binding; cofactor binding; enzyme binding; oxidoreductase activity; protein binding; protein dimerization activity
Biological Process: cellular response to transforming growth factor beta stimulus; intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of transcription from RNA polymerase II promoter; negative regulation of Wnt signaling pathway; osteoblast differentiation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of transcription from RNA polymerase II promoter; skeletal morphogenesis; steroid metabolic process; transcription from RNA polymerase II promoter; Wnt signaling pathway
Disease: Epileptic Encephalopathy, Early Infantile, 28; Spinocerebellar Ataxia, Autosomal Recessive 12
Research Articles on WWOX
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Product Notes
The Human, Mouse WWOX wwox (Catalog #AAA9500629) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500629 ELISA Kit recognizes Human, Mouse WWOX. It is sometimes possible for the material contained within the vial of "WWOX, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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