Human, Mouse DJ-1 ELISA Kit | DJ-1 elisa kit
DJ-1 Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
DJ-1: associated with autosomal recessive early onset parkinsonism. Involved in the oxidative stress response. Three cysteines in DJ-1 may be oxidized to cysteine sulphonic acid in the cellular response to H2O2. Loss of DJ-1 function may lead to neurodegeneration.
Protein type: EC 3.4.-.-; Nuclear receptor co-regulator; Transcription regulation; Tumor suppressor
Chromosomal Location of Human Ortholog: 1p36.23
Cellular Component: axon; cell body; cell-cell adherens junction; chromatin; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; membrane raft; mitochondrial intermembrane space; mitochondrial matrix; mitochondrial respiratory chain complex I; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane; PML body; presynapse
Molecular Function: androgen receptor binding; cadherin binding; copper ion binding; cytokine binding; double-stranded DNA binding; enzyme binding; identical protein binding; kinase binding; L-dopa decarboxylase activator activity; mercury ion binding; mRNA binding; oxidoreductase activity, acting on peroxide as acceptor; peptidase activity; peroxiredoxin activity; protein binding; protein deglycase activity; protein homodimerization activity; receptor binding; single-stranded DNA binding; small protein activating enzyme binding; superoxide dismutase copper chaperone activity; transcription coactivator activity; transcription factor binding; tyrosine 3-monooxygenase activator activity; ubiquitin-like protein conjugating enzyme binding; ubiquitin-specific protease binding
Biological Process: activation of protein kinase B activity; adult locomotory behavior; autophagy; cellular oxidant detoxification; cellular response to glyoxal; cellular response to hydrogen peroxide; cellular response to oxidative stress; detoxification of copper ion; detoxification of mercury ion; DNA repair; dopamine uptake; enzyme active site formation via L-cysteine sulfinic acid; glucose homeostasis; glutathione deglycation; glycolate biosynthetic process; guanine deglycation; guanine deglycation, glyoxal removal; guanine deglycation, methylglyoxal removal; hydrogen peroxide metabolic process; inflammatory response; insulin secretion; lactate biosynthetic process; membrane depolarization; membrane hyperpolarization; methylglyoxal metabolic process; mitochondrion organization; negative regulation of apoptosis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of gene expression; negative regulation of neuron apoptosis; negative regulation of neuron death; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein acetylation; negative regulation of protein binding; negative regulation of protein export from nucleus; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; negative regulation of protein sumoylation; negative regulation of protein ubiquitination; negative regulation of ubiquitin-protein ligase activity; negative regulation of ubiquitin-specific protease activity; peptidyl-arginine deglycation; peptidyl-cysteine deglycation; peptidyl-lysine deglycation; positive regulation of acute inflammatory response to antigenic stimulus; positive regulation of androgen receptor activity; positive regulation of gene expression; positive regulation of interleukin-8 production; positive regulation of NAD(P)H oxidase activity; positive regulation of oxidative phosphorylation uncoupler activity; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein homodimerization activity; positive regulation of protein kinase B signaling; positive regulation of protein localization to nucleus; positive regulation of superoxide dismutase activity; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription regulatory region DNA binding; protein deglycation, glyoxal removal; protein deglycation, methylglyoxal removal; protein deglycosylation; protein stabilization; proteolysis; Ras protein signal transduction; regulation of inflammatory response; regulation of mitochondrial membrane potential; regulation of neuron apoptosis; regulation of TRAIL receptor biosynthetic process; single fertilization
Disease: Parkinson Disease 7, Autosomal Recessive Early-onset
Research Articles on DJ-1
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Product Notes
The Human, Mouse DJ-1 park7 (Catalog #AAA9500179) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500179 ELISA Kit recognizes Human, Mouse DJ-1. It is sometimes possible for the material contained within the vial of "DJ-1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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