Rabbit AQP7 Polyclonal Antibody | anti-AQP7 antibody

AQP7 Antibody FITC Conjugated

Cat. Num. AAA9461056

• Gene Names: AQP7; AQP9; AQP7L; AQPap; GLYCQTL
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence
• Purity: Purified by Protein A
• Synonyms: AQP7; Polyclonal Antibody; AQP7 Antibody FITC Conjugated; AQP9; AQP7L; AQPap; GLYCQTL; Aquaporin-7; AQP-7; Aquaglyceroporin-7; Aquaporin adipose; Aquaporin-7-like; anti-AQP7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A
• Form/Format: 10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Concentration: 1mgml (varies by lot)

• Applicable Applications for anti-AQP7 antibody: Immunofluorescence (IF)
• Application Notes: IF: 1:50-200
• Conjugation: FITC
• Excitation Emission: 494nm 518nm
• Immunogen: KLH conjugated synthetic peptide aa 205-240 242 derived from human AQP7
• Preparation and Storage: Store at 4 degree C for 12 months.

Related Product Information for anti-AQP7 antibody

Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein "aquaporin". Over the last decade, genes for several members of aquaporin family have been cloned, expressed, and their distribution studied in many tissues. AQP0 or MIP26 (major intrinsic protein 26kD), and Aquaporin 1 (AQP1, purified from red cells) also called CHIP28 (channel forming integral protein, 28kD; 268aa; gene locus 7p14) has been the foundation of the growing family of aquaporin. The lens specific AQP0 represents up to 80% of total lens membrane protein. Defects in MIP26 are cause of autosomal dominant cataract. The cataract Fraser mutation (CATFR or Shriveled) is a transposon induced splicing error that substitutes a long terminal repeat sequence for the C terminus of MIP. The lens opacity mutation (LOP) is an amino acid substitution that inhibits targeting of MIP to the cell membrane.

Product Categories/Family for anti-AQP7 antibody

Conjugated Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 3121761
• NCBI GeneID: 364
• UniProt Accession #: O14520; Q08E94; Q5T5L9; Q8NHM3
• Molecular Weight: 17,954 Da
• NCBI Official Full Name: Aquaporin-7
• NCBI Official Synonym Full Names: aquaporin 7
• NCBI Official Symbol: AQP7
• NCBI Official Synonym Symbols: AQP9; AQP7L; AQPap; GLYCQTL
• NCBI Protein Information: aquaporin-7; AQP-7; aquaporin adipose; aquaglyceroporin-7
• UniProt Protein Name: Aquaporin-7
• Protein Family: Aquaporin
• UniProt Gene Name: AQP7
• UniProt Synonym Gene Names: AQP7L; AQP9; AQP-7; AQPap
• UniProt Entry Name: AQP7_HUMAN

NCBI Description

Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in sperm function. [provided by RefSeq, Jul 2008]

Uniprot Description

AQP7: Forms a channel for water and glycerol. Belongs to the MIP/aquaporin (TC 1.A.8) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; intercellular junction

Molecular Function: urea transmembrane transporter activity; water channel activity; glycerol channel activity

Biological Process: glycerol transport; generation of precursor metabolites and energy; cellular water homeostasis; water transport; excretion; transmembrane transport

Disease: Glycerol Quantitative Trait Locus