Rabbit TRAF6 Polyclonal Antibody | anti-TRAF6 antibody

TRAF6 Antibody FITC Conjugated

Cat. Num. AAA9460435

• Gene Names: Traf6; AI851288; 2310003F17Rik; C630032O20Rik
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence
• Purity: Purified by Protein A
• Synonyms: TRAF6; Polyclonal Antibody; TRAF6 Antibody FITC Conjugated; AI851288; 2310003F17Rik; C630032O20Rik; TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6; Traf6; anti-TRAF6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A
• Form/Format: 10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Concentration: 1mgml (varies by lot)

• Applicable Applications for anti-TRAF6 antibody: Immunofluorescence (IF)
• Application Notes: IF: 1:50-200
• Conjugation: FITC
• Excitation Emission: 494nm 518nm
• Immunogen: KLH conjugated synthetic peptide aa 500-530 530 derived from mouse TRAF6
• Preparation and Storage: Store at 4 degree C for 12 months.

Related Product Information for anti-TRAF6 antibody

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity). Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Product Categories/Family for anti-TRAF6 antibody

Conjugated Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 38348246
• NCBI GeneID: 22034
• NCBI Accession #: NP_033450.2
• NCBI GenBank Nucleotide #: NM_009424.2
• UniProt Accession #: P70196; Q6P9M0; Q8BLV2
• Molecular Weight: 60,070 Da
• NCBI Official Full Name: TNF receptor-associated factor 6
• NCBI Official Synonym Full Names: TNF receptor-associated factor 6
• NCBI Official Symbol: Traf6
• NCBI Official Synonym Symbols: AI851288; 2310003F17Rik; C630032O20Rik
• NCBI Protein Information: TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6
• UniProt Protein Name: TNF receptor-associated factor 6
• Protein Family: TNF receptor-associated factor
• UniProt Gene Name: Traf6
• UniProt Entry Name: TRAF6_MOUSE

NCBI Description

This gene encodes a member of the TNF receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin ligase activity. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Description

Function: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.7 PublicationsManual assertion based on experiment in:Ref.5