Rabbit anti-Mouse, Rat ARIP2B Polyclonal Antibody | anti-ARIP2B antibody
ARIP2B Antibody FITC Conjugated
NCBI and Uniprot Product Information
NCBI Description
plays a role in reproductive physiology and endocrinology [RGD, Feb 2006]
Uniprot Description
ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.
Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily
Chromosomal Location of Human Ortholog: 8q32
Cellular Component: cytoplasm; integral component of membrane; plasma membrane; protein complex; receptor complex
Molecular Function: activin binding; ATP binding; growth factor binding; metal ion binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; signal transducer, downstream of receptor, with serine/threonine kinase activity; transforming growth factor beta binding; transmembrane receptor protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; activin receptor signaling pathway; anterior/posterior pattern specification; blood vessel remodeling; BMP signaling pathway; determination of left/right symmetry; embryonic foregut morphogenesis; gastrulation with mouth forming second; heart development; insulin secretion; kidney development; lung development; lymphangiogenesis; mesoderm development; negative regulation of transcription from RNA polymerase II promoter; odontogenesis of dentine-containing teeth; organ growth; palate development; pancreas development; pattern specification process; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; post-embryonic development; protein amino acid phosphorylation; regulation of signal transduction; regulation of transcription, DNA-templated; response to glucose stimulus; sexual reproduction; signal transduction; skeletal morphogenesis; skeletal system development; transmembrane receptor protein serine/threonine kinase signaling pathway