Rabbit anti-Human, Rat FKBP51 Monoclonal Antibody | anti-FKBP51 antibody
FKBP51 Conjugated Antibody
Gene Names
FKBP5; P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10
Reactivity
Human, Rat
Applications
Most Applications
Synonyms
FKBP51; Monoclonal Antibody; FKBP51 Conjugated Antibody; 51 kDa FK506 binding protein 5 antibody; 51 kDa FK506 binding protein antibody; 51 kDa FK506-binding protein antibody; 51 kDa FKBP antibody; 54 kDa progesterone receptor associated immunophilin antibody; 54 kDa progesterone receptor-associated immunophilin antibody; AIG 6 antibody; AIG6 antibody; Androgen regulated protein 6 antibody; Androgen-regulated protein 6 antibody; FF1 antigen antibody; FK506 binding protein 5 antibody; FK506-binding protein 5 antibody; FKBP 5 antibody; FKBP 51 antibody; FKBP 54 antibody; FKBP-5 antibody; FKBP-51 antibody; FKBP5 antibody; FKBP5_HUMAN antibody; FKBP54 antibody; HSP90 binding immunophilin antibody; HSP90-binding immunophilin antibody; MGC111006 antibody; OTTHUMP00000016268 antibody; P54 antibody; Peptidyl prolyl cis trans isomerase antibody; Peptidyl-prolyl cis-trans isomerase FKBP5 antibody; Peptidylprolyl cis trans isomerase antibody; PPIase antibody; PPIase FKBP5 antibody; Ptg 10 antibody; Ptg10 antibody; Rotamase antibody; T cell FK506 binding protein antibody; anti-FKBP51 antibody
Host
Rabbit
Reactivity
Human, Rat
Clonality
Monoclonal
Form/Format
0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
Applicable Applications for anti-FKBP51 antibody
Most Applications
Application Notes
Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
Antibody Type
Recombinant Antibody
Immunogen
Recombinant protein
Conjugation
Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
Excitation Emission
AF350: 346nm/442nm
Preparation and Storage
Store at 4 degree C for 6 months.
Related Product Information for anti-FKBP51 antibody
The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin. Several related immunophilins, FKBP12, FKBP51 and FKBP52, are characterized as cytosolic FK506-binding proteins, and following ligand binding, they functionally inhibit the phosphatase activity of calcineurin. The ubiquitously expressed FKBP12 also associates with the cytoplasmic domain of the TGFbeta-type I receptor, where it stabilizes the inactive conformation of the receptor and blocks the activation of the TGFbeta pathway. FKBP51 and FKBP52 are two highly related proteins. FKBP51 is predominantly expressed in T cells and is induced by glucocorticoids. FKBP51 mediates the effects of FK506 and rapamycin by inhibiting intracellular calcineurin activity, and by blocking T-cell activation and proliferation. FKBP52, known also as FKBP-59 or heat shock protein 56, is expressed in a variety of tissues and can also associate with the heat shock protein (hsp90) in mature steroid receptor complexes (6, 8).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
457
NCBI Official Full Name
Peptidyl-prolyl cis-trans isomerase FKBP5
NCBI Official Synonym Full Names
FK506 binding protein 5
NCBI Official Symbol
FKBP5
NCBI Official Synonym Symbols
P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase FKBP5; FKBP-51; rotamase; 51 kDa FKBP; FF1 antigen; PPIase FKBP5; HSP90-binding immunophilin; 51 kDa FK506-binding protein; T-cell FK506-binding protein; androgen-regulated protein 6; peptidylprolyl cis-trans isomerase;
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP5
UniProt Gene Name
FKBP5
UniProt Synonym Gene Names
AIG6; FKBP51; PPIase FKBP5; 51 kDa FKBP; FKBP-51; FKBP-5; p54
UniProt Entry Name
FKBP5_HUMAN
NCBI Description
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Uniprot Description
FKBP5: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid. By androgen. Widely expressed, enriched in testis compared to other tissues. Inhibited by FK506 but not cyclosporin.
Protein type: EC 5.2.1.8; Isomerase; Chaperone
Chromosomal Location of Human Ortholog: 6p21.31
Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane
Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; heat shock protein binding
Biological Process: protein peptidyl-prolyl isomerization; protein folding
Disease: Major Depressive Disorder
Research Articles on FKBP51
Similar Products
Product Notes
The FKBP51 fkbp5 (Catalog #AAA9457425) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FKBP51 Conjugated Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's FKBP51 can be used in a range of immunoassay formats including, but not limited to, Most Applications. Suggested Dilution: AF350 conjugated: most applications: 1:50-1:250 AF405 conjugated: most applications: 1:50-1:250 AF488 conjugated: most applications: 1:50-1:250 AF555 conjugated: most applications: 1:50-1:250 AF594 conjugated: most applications: 1:50-1:250 AF647 conjugated: most applications: 1:50-1:250 AF680 conjugated: most applications: 1:50-1:250 AF750 conjugated: most applications: 1:50-1:250 Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000. Researchers should empirically determine the suitability of the FKBP51 fkbp5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FKBP51, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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