Rabbit anti-Human, Mouse SAP 155 Polyclonal Antibody | anti-SAP155 antibody

SAP 155 Conjugated Antibody

Cat. Num. AAA9453338

• Gene Names: SF3B1; MDS; PRP10; Hsh155; PRPF10; SAP155; SF3b155
• Reactivity: Human, Mouse
• Applications: Most Applications
• Synonyms: SAP 155; Polyclonal Antibody; SAP 155 Conjugated Antibody; SF3B1; Hsh155; MDS; PRP10; PRPF10; Splicing factor 3B subunit 1; SAP155; SF3b155; anti-SAP155 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: SAP 155 antibody detects endogenous levels of total SAP 155
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-SAP155 antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: A synthesized peptide derived from human SAP 155
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

NCBI and Uniprot Product Information

• NCBI GI #: 54112117
• NCBI GeneID: 23451
• NCBI Accession #: NP_036565.2
• NCBI GenBank Nucleotide #: NM_012433.2
• UniProt Accession #: O75533; E9PCH3
• Molecular Weight: 16,020 Da
• NCBI Official Full Name: splicing factor 3B subunit 1 isoform 1
• NCBI Official Synonym Full Names: splicing factor 3b, subunit 1, 155kDa
• NCBI Official Symbol: SF3B1
• NCBI Official Synonym Symbols: MDS; PRP10; Hsh155; PRPF10; SAP155; SF3b155
• NCBI Protein Information: splicing factor 3B subunit 1; SAP 155; pre-mRNA processing 10; spliceosome-associated protein 155; splicing factor 3b, subunit 1, 155kD; pre-mRNA splicing factor SF3b, 155 kDa subunit
• UniProt Protein Name: Splicing factor 3B subunit 1
• Protein Family: SIT4-associating protein
• UniProt Gene Name: SF3B1
• UniProt Synonym Gene Names: SAP155; SF3b155; SAP 155
• UniProt Entry Name: SF3B1_HUMAN

NCBI Description

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

SF3B1: subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (bps) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Phosphorylated during the splicing catalytic steps.

Protein type: Spliceosome; RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: 2q33.1

Cellular Component: nucleoplasm; spliceosome; nuclear speck; nucleus; U12-dependent spliceosome

Molecular Function: protein binding; chromatin binding

Biological Process: anterior/posterior pattern formation; nuclear mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; RNA splicing; gene expression

Disease: Myelodysplastic Syndrome