Rabbit GABBR1 Polyclonal Antibody | anti-GABBR1 antibody

GABBR1 Conjugated Antibody

Cat. Num. AAA9448021

• Gene Names: SLC6A1; MAE; GAT1; GABATR; GABATHG
• Reactivity: Human, Mouse, Rat
• Applications: Most Applications
• Synonyms: GABBR1; Polyclonal Antibody; GABBR1 Conjugated Antibody; GB1; GPRC3A; GABABR1; GABBR1-3; dJ271M21.1.1; dJ271M21.1.2; anti-GABBR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total GABBR1 protein.
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-GABBR1 antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human gamma-aminobutyric acid (GABA) B receptor, 1
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

Related Product Information for anti-GABBR1 antibody

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA (A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA (B)] receptors, to produce slow, prolonged inhibitory signals. The GABA (B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA (B) receptor 1 and GABA (B) receptor 2. The GABA (B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 188528618
• NCBI GeneID: 6529
• NCBI Accession #: NP_003033
• NCBI GenBank Nucleotide #: NM_003042
• UniProt Accession #: Q9UBS5; P30531
• Molecular Weight: 67kDa
• NCBI Official Full Name: sodium- and chloride-dependent GABA transporter 1 isoform a
• NCBI Official Synonym Full Names: solute carrier family 6 member 1
• NCBI Official Symbol: SLC6A1
• NCBI Official Synonym Symbols: MAE; GAT1; GABATR; GABATHG
• NCBI Protein Information: sodium- and chloride-dependent GABA transporter 1
• UniProt Protein Name: Gamma-aminobutyric acid type B receptor subunit 1
• Protein Family: Gamma-aminobutyric acid type B receptor
• UniProt Gene Name: GABBR1
• UniProt Synonym Gene Names: GPRC3A; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1
• UniProt Entry Name: GABR1_HUMAN

NCBI Description

The protein encoded by this gene is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals. [provided by RefSeq, Jan 2017]

Uniprot Description

GABBR1: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1. Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 3

Chromosomal Location of Human Ortholog: 6p21.31

Cellular Component: presynaptic membrane; postsynaptic membrane; integral to plasma membrane; cytoplasm; dendrite; plasma membrane; extracellular region; cell junction

Molecular Function: protein binding; GABA-B receptor activity

Biological Process: synaptic transmission; negative regulation of adenylate cyclase activity; G-protein signaling, adenylate cyclase inhibiting pathway; gamma-aminobutyric acid signaling pathway