Rabbit anti-Human FPR3 Polyclonal Antibody | anti-FPR3 antibody

FPR3 Conjugated Antibody

Cat. Num. AAA9448015

• Gene Names: FOLH1B; PSM; GCP3; FOLH2; FOLHP; PSMAL; GCPIII; PSMA-LIKE
• Reactivity: Human
• Applications: Most Applications
• Synonyms: FPR3; Polyclonal Antibody; FPR3 Conjugated Antibody; FMLPY; FPRH1; FPRH2; FPRL2; RMLP-R-I; FML2_HUMAN; anti-FPR3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total FPR3 protein.
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
• Sequence Length: 442

• Applicable Applications for anti-FPR3 antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: Synthetic peptide corresponding to residues near the C terminal of human formyl peptide receptor 3
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

Related Product Information for anti-FPR3 antibody

The N-formyl peptide receptor (FPR) family is comprised of three members, FPR, FPR3 (also designated FPRL1, lipoxin A4 receptor, FPRH1 or FPR2) and FPR like-2 (FPRL2), all of which are chemotactic G protein-coupled receptors that contain seven transmembrane domains. These receptors are found on the surface of phagocytic leukocytes, such as neutrophils and monocytes, and each family member contains specific residues, which are responsible for determining its ligand specificity. FPR3 is a promiscuous receptor that binds to several ligands, including lipoxin A4, N-formyl-methionyl-leucyl-phenylalanine (fMLP), serum amyloid A (SAA), prion peptide and the 42 amino acid form of beta amyloid. Upon activation, FPR3 induces migration and calcium mobilization in human monocytes and neutrophils and is involved in inflammatory and host defense responses. FPR3 may mediate inflammation in prion and Alzheimerïs diseases, which makes it a potential target for therapeutic agents.

NCBI and Uniprot Product Information

• NCBI GI #: 24308545
• NCBI GeneID: 219595
• NCBI Accession #: NP_710163
• NCBI GenBank Nucleotide #: NP_710163.1
• UniProt Accession #: P25089; Q9HBA9
• NCBI Official Full Name: putative N-acetylated-alpha-linked acidic dipeptidase
• NCBI Official Synonym Full Names: folate hydrolase 1B
• NCBI Official Symbol: FOLH1B
• NCBI Official Synonym Symbols: PSM; GCP3; FOLH2; FOLHP; PSMAL; GCPIII; PSMA-LIKE
• NCBI Protein Information: putative N-acetylated-alpha-linked acidic dipeptidase
• UniProt Protein Name: N-formyl peptide receptor 3
• Protein Family: FK506-binding protein
• UniProt Gene Name: FPR3
• UniProt Synonym Gene Names: FPRH1; FPRL2; FMLP-R-II
• UniProt Entry Name: FPR3_HUMAN

Uniprot Description

FPR3: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: integral to membrane; plasma membrane

Molecular Function: N-formyl peptide receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; cell motility; chemotaxis; signal transduction