Rabbit anti-Human, Mouse KIF3A Polyclonal Antibody | anti-KIF3A antibody

KIF3A Conjugated Antibody

Cat. Num. AAA9446258

• Gene Names: KIF3A; FLA10; KLP-20
• Reactivity: Human, Mouse
• Applications: Most Applications
• Synonyms: KIF3A; Polyclonal Antibody; KIF3A Conjugated Antibody; FLA10; KLP-20; anti-KIF3A antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total KIF3A protein.
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
• Sequence Length: 3292

• Applicable Applications for anti-KIF3A antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: Fusion protein corresponding to a region derived from internal residues of human kinesin family member 3A
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

Related Product Information for anti-KIF3A antibody

Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene. Members of the heterotrimeric kinesin II family of microtubule associated motors generally contain two different motor subunits from the KIF3 family, which includes KIF3A, B and C. KIF3 isoforms mediate anterograde transport of membrane bound organelles in neurons and melanosomes, transport between the endoplasmic reticulum and the Golgi, and transport of protein complexes within cilia and flagella required for their morphogenesis. KIF3A may influence neurogenesis at the level of embryonic cellular events, where the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination is defined. Loss of KIF3A function in mice photoreceptors causes apoptotic cell death, suggesting that kinesin II mediated transport is required for proper cell fate.

NCBI and Uniprot Product Information

• NCBI GI #: 28278541
• NCBI GeneID: 11127
• UniProt Accession #: Q9Y496
• Molecular Weight: 80
• NCBI Official Full Name: Homo sapiens kinesin family member 3A, mRNA
• NCBI Official Synonym Full Names: kinesin family member 3A
• NCBI Official Symbol: KIF3A
• NCBI Official Synonym Symbols: FLA10; KLP-20
• NCBI Protein Information: kinesin-like protein KIF3A
• UniProt Protein Name: Kinesin-like protein KIF3A
• Protein Family: Kinesin-like protein
• UniProt Gene Name: KIF3A
• UniProt Synonym Gene Names: KIF3
• UniProt Entry Name: KIF3A_HUMAN

Uniprot Description

KIF3A: Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Heterodimer of KIF3A and KIF3B. Interacts with PIFO/C1orf88. Interacts with CLN3. Belongs to the kinesin-like protein family. Kinesin II subfamily.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: centrosome; cytosol; kinesin II complex; microtubule cytoskeleton; spindle microtubule

Molecular Function: ATP binding; microtubule binding; plus-end-directed microtubule motor activity; protein binding; spectrin binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; cilium biogenesis; metabolic process; microtubule-based movement; neurogenesis; organelle organization and biogenesis; retrograde vesicle-mediated transport, Golgi to ER