Rabbit anti-Human RUNX3 Polyclonal Antibody | anti-RUNX3 antibody

RUNX3 Conjugated Antibody

Cat. Num. AAA9446003

• Gene Names: RUNX3; AML2; CBFA3; PEBP2aC
• Reactivity: Human
• Applications: Most Applications
• Synonyms: RUNX3; Polyclonal Antibody; RUNX3 Conjugated Antibody; Acute myeloid leukemia 2 protein; acute myeloid leukemia gene 2; AML2; CBF-alpha-3; CBFA3; anti-RUNX3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total RUNX3 protein.
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-RUNX3 antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: Synthesized peptide derived from Internal of human RUNX3.
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

Related Product Information for anti-RUNX3 antibody

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.

NCBI and Uniprot Product Information

• NCBI GI #: 72534652
• NCBI GeneID: 864
• NCBI Accession #: NP_001026850.1
• NCBI GenBank Nucleotide #: NM_001031680.2
• UniProt Accession #: Q13761; Q12969; Q13760; B1AJV5
• Molecular Weight: 44,356 Da
• NCBI Official Full Name: runt-related transcription factor 3 isoform 1
• NCBI Official Synonym Full Names: runt-related transcription factor 3
• NCBI Official Symbol: RUNX3
• NCBI Official Synonym Symbols: AML2; CBFA3; PEBP2aC
• NCBI Protein Information: runt-related transcription factor 3; CBF-alpha-3; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2-alpha C; oncogene AML-2; transcription factor AML2; acute myeloid leukemia gene 2; acute myeloid leukemia 2 protein; core-binding factor subunit alpha-3; SL
• UniProt Protein Name: Runt-related transcription factor 3
• Protein Family: Runt-related transcription factor
• UniProt Gene Name: RUNX3
• UniProt Synonym Gene Names: AML2; CBFA3; PEBP2A3; CBF-alpha-3; PEA2-alpha C
• UniProt Entry Name: RUNX3_HUMAN

NCBI Description

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

AML2: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA- binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; nuclear chromatin; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; transcription factor activity; ATP binding

Biological Process: peripheral nervous system neuron development; transcription from RNA polymerase II promoter; axon guidance; hair follicle morphogenesis; regulation of transcription, DNA-dependent; cell maturation; interferon-gamma production; chondrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; negative regulation of epithelial cell proliferation; negative regulation of cell cycle