Rabbit anti-Human UPP1 Polyclonal Antibody | anti-UPP1 antibody
UPP1 Polyclonal Antibody
NCBI and Uniprot Product Information
Actual Protein Molecular Mass: 18; 41 kDa
NCBI Description
This gene encodes a uridine phosphorylase, an enzyme that catalyzes the reversible phosphorylation of uridine (or 2'- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded enzyme functions in the degradation and salvage of pyrimidine ribonucleosides. [provided by RefSeq, Oct 2016]
Uniprot Description
UPP1: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; EC 2.4.2.3; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 7p12.3
Cellular Component: cytosol
Molecular Function: uridine phosphorylase activity
Biological Process: cellular response to glucose starvation; pyrimidine nucleoside catabolic process; uridine metabolic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; nucleotide catabolic process; pyrimidine nucleoside salvage