Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 46651(RBL2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200))
Rabbit anti-Human, Rat RBL2 Polyclonal Antibody | anti-RBL2 antibody
RBL2 Antibody
Gene Names
RBL2; Rb2; P130
Reactivity
Human, Rat
Applications
Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
RBL2; Polyclonal Antibody; RBL2 Antibody; Rb2; P130; anti-RBL2 antibody
Host
Rabbit
Reactivity
Human, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
The antibody detects endogenous levels of total RBL2 protein.
Purity/Purification
Antigen affinity purification
Form/Format
In pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
1.1mg/ml (varies by lot)
Sequence Length
1139
Applicable Applications for anti-RBL2 antibody
Immunohistochemistry (IHC)
Application Notes
IHC: 1: 30-150
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human RBL2
Immunogen Type
Peptide
Preparation and Storage
Store at -20 degree C.
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 46651(RBL2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 46651(RBL2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200))
Related Product Information for anti-RBL2 antibody
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Product Categories/Family for anti-RBL2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
59,349 Da
NCBI Official Full Name
retinoblastoma-like protein 2 isoform 1
NCBI Official Synonym Full Names
RB transcriptional corepressor like 2
NCBI Official Symbol
RBL2
NCBI Official Synonym Symbols
Rb2; P130
NCBI Protein Information
retinoblastoma-like protein 2
UniProt Protein Name
Retinoblastoma-like protein 2
Protein Family
UniProt Gene Name
RBL2
UniProt Synonym Gene Names
RB2; p130; RBR-2
Uniprot Description
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Research Articles on RBL2
Similar Products
Product Notes
The RBL2 rbl2 (Catalog #AAA9429798) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RBL2 Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's RBL2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1: 30-150. Researchers should empirically determine the suitability of the RBL2 rbl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RBL2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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