Mouse Low-density lipoprotein receptor-related protein 8 ELISA Kit | Lrp8 elisa kit
Mouse Low-density lipoprotein receptor-related protein 8 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
LRP8: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Defects in LRP8 are a cause of myocardial infarction type 1 (MCI1). A condition defined by the irreversible necrosis of heart muscle secondary to prolonged ischemia. Belongs to the LDLR family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 4|4 C7
Cellular Component: axon; caveola; cell soma; dendrite; extracellular space; membrane; microtubule associated complex; plasma membrane; postsynaptic density; receptor complex
Molecular Function: apolipoprotein binding; calcium-dependent protein binding; glycoprotein binding; high-density lipoprotein binding; kinesin binding; low-density lipoprotein receptor activity; protein binding; very-low-density lipoprotein receptor activity
Biological Process: activation of CREB transcription factor; ammon gyrus development; dendrite morphogenesis; endocytosis; hippocampus development; layer formation in the cerebral cortex; negative regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; regulation of synaptic transmission; synaptic transmission; ventral spinal cord development
Research Articles on Lrp8
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Product Notes
The Mouse Lrp8 lrp8 (Catalog #AAA9426349) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9426349 ELISA Kit recognizes Mouse Lrp8. It is sometimes possible for the material contained within the vial of "Low-density lipoprotein receptor-related protein 8, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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