Cytoplasmic dynein 2 light intermediate chain 1 (DYNC2LI1) Recombinant Protein | DYNC2LI1 recombinant protein
Recombinant Human Cytoplasmic dynein 2 light intermediate chain 1 (DYNC2LI1)
Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
Uniprot Description
DYNC2LI1: May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. Belongs to the dynein light intermediate chain family. 5 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 2p21
Cellular Component: apical part of cell; axoneme; centrosome; cilium; cytoplasm; cytoplasmic dynein complex; cytoplasmic microtubule
Molecular Function: dynein heavy chain binding; minus-end-directed microtubule motor activity; protein binding
Disease: Short-rib Thoracic Dysplasia 15 With Polydactyly
Research Articles on DYNC2LI1
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Product Notes
The DYNC2LI1 dync2li1 (Catalog #AAA9424295) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Full Length of isoform 2, 1-352aa. The Recombinant Human Cytoplasmic dynein 2 light intermediate chain 1 (DYNC2LI1) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Cytoplasmic dynein 2 light intermediate chain 1 (DYNC2LI1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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