Beclin-1 (Becn1) Recombinant Protein | Becn1 recombinant protein

Recombinant Mouse Beclin-1 (Becn1)

Cat. Num. AAA9424141

• Reactivity: Mouse
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Beclin-1 (Becn1); Recombinant Mouse Beclin-1 (Becn1); Coiled-coil myosin-like BCL2-interacting protein; Becn1 recombinant protein

• Host: E Coli
• Reactivity: Mouse
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: Tris-based buffer, 50% glycerol
• Sequence Positions: Full Length, 1-448aa

• Tag Info: N-terminal 6xHis-SUMO-tagged
• Preparation and Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.; Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.

Related Product Information for Becn1 recombinant protein

Plays a central role in autophagy (PubMed:10604474, PubMed:12372286, PubMed:19270693). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:19270693, PubMed:25275521). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (PubMed:25275521). Involved in endocytosis including endosome formation in neuronal cells (PubMed:25275521). May play a role in antiviral host defense (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 27764875
• NCBI GeneID: 56208
• NCBI Accession #: NP_062530.2
• NCBI GenBank Nucleotide #: NM_019584.3
• UniProt Accession #: O88597; Q99J03
• Molecular Weight: 67.56 kDa
• NCBI Official Full Name: beclin-1
• UniProt Protein Name: Beclin-1
• Protein Family: Beclin
• UniProt Gene Name: Becn1

Uniprot Description

beclin 1: an essential autophagy protein that has been linked to multiple processes including tumor suppression, protection against some cardiac and neurological degenerative diseases, and lifespan extension. A ubiquitous protein of the beclin family. Is part of the class III PI3K complex that induces autophagy. Expressed at elevated levels in dendrites and cell bodies of cerebellar Purkinje cells. Interacts with the anti-apoptotic protein Bcl-2, which inhibits autophagy when it is present in the endoplasmic reticulum. The dissociation of ATG6 from Bcl-2 is essential for its autophagic activity. Interacts with PITC and GluR-delta2. Probably forms a complex with AMBRA1 and PIK3C3. Plays a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.

Protein type: Adaptor/scaffold; Autophagy; Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 11|11 D

Cellular Component: autophagic vacuole; cytoplasm; cytoplasmic vesicle; cytoskeleton; dendrite; endoplasmic reticulum; endosome; extrinsic to membrane; membrane; mitochondrion; nucleus; phagocytic vesicle; protein complex; trans-Golgi network

Molecular Function: GTPase binding; phosphoinositide 3-kinase binding; protein binding; ubiquitin protein ligase binding

Biological Process: angiogenesis; autophagic vacuole formation; autophagy; beta-amyloid metabolic process; cellular response to glucose starvation; cellular response to nitrogen starvation; cytokinesis; engulfment of apoptotic cell; late endosome to vacuole transport; lysosome organization and biogenesis; macroautophagy; macromitophagy; mitochondrion degradation; mitotic metaphase plate congression; negative regulation of apoptosis; negative regulation of cell proliferation; neuron development; positive regulation of autophagy; receptor catabolic process; regulation of catalytic activity; regulation of cytokinesis; response to other organism