Glyoxylate reductase/hydroxypyruvate reductase (Glxr) Recombinant Protein | Glxr recombinant protein

Recombinant Mouse Glyoxylate reductase/hydroxypyruvate reductase (Glxr)

Cat. Num. AAA9423612

• Gene Names: Grhpr; Glxr; 1110059D05Rik; 6430629L09Rik
• Reactivity: Mouse
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Glyoxylate reductase/hydroxypyruvate reductase (Glxr); Recombinant Mouse Glyoxylate reductase/hydroxypyruvate reductase (Glxr); Glxr recombinant protein

• Host: E Coli
• Reactivity: Mouse
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: Tris-based buffer, 50% glycerol
• Sequence Positions: Full Length, 1-328aa

• Tag Info: N-terminal 6xHis-SUMO-tagged
• Preparation and Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.; Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 17933768
• NCBI GeneID: 76238
• NCBI Accession #: NP_525028.1
• NCBI GenBank Nucleotide #: NM_080289.2
• UniProt Accession #: Q91Z53
• Molecular Weight: 52.08 kDa
• NCBI Official Full Name: glyoxylate reductase/hydroxypyruvate reductase isoform 1
• NCBI Official Synonym Full Names: glyoxylate reductase/hydroxypyruvate reductase
• NCBI Official Symbol: Grhpr
• NCBI Official Synonym Symbols: Glxr; 1110059D05Rik; 6430629L09Rik
• NCBI Protein Information: glyoxylate reductase/hydroxypyruvate reductase
• UniProt Protein Name: Glyoxylate reductase/hydroxypyruvate reductase
• UniProt Gene Name: Grhpr
• UniProt Synonym Gene Names: Glxr

NCBI Description

This gene encodes a member of the D-isomer specific 2-hydroxyacid dehydrogenase family of proteins. The encoded protein catalyzes three enzymatic reactions: the conversion of hydroxypyruvate to D-glycerate as well as the reverse reaction, and the conversion of glyoxylate to glycolate. Homozygous knockout mice exhibit elevated synthesis of oxalate and glycerate. [provided by RefSeq, Aug 2015]

Uniprot Description

GRHPR: Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2); also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L- glycerate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Protein type: Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.79; EC 1.1.1.81; Oxidoreductase

Chromosomal Location of Human Ortholog: 4|4 B1

Cellular Component: cytoplasm; cytosol

Molecular Function: carboxylic acid binding; glycerate dehydrogenase activity; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; NAD binding; NADP binding; protein homodimerization activity

Biological Process: dicarboxylic acid metabolic process; excretion; protein oligomerization