Transcription elongation factor B polypeptide 1 Recombinant Protein | ELOC recombinant protein

Recombinant Human Transcription elongation factor B polypeptide 1

Cat. Num. AAA9420728

• Gene Names: ELOC; SIII; TCEB1
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Transcription elongation factor B polypeptide 1; Recombinant Human Transcription elongation factor B polypeptide 1; Elongin 15 kDa subunitElongin-C; EloCRNA polymerase II transcription factor SIII subunit CSIII p15; ELOC recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 1-112aa

• Tag Info: GST-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for ELOC recombinant protein

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past tplate-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

NCBI and Uniprot Product Information

• NCBI GI #: 325652033
• NCBI GeneID: 6921
• NCBI Accession #: NP_001191786.1
• NCBI GenBank Nucleotide #: NM_001204857.1
• UniProt Accession #: Q15369; Q567Q6; E5RGD9
• Molecular Weight: 39.9kD
• NCBI Official Full Name: elongin-C isoform a
• NCBI Official Synonym Full Names: elongin C
• NCBI Official Symbol: ELOC
• NCBI Official Synonym Symbols: SIII; TCEB1
• NCBI Protein Information: elongin-C; transcription elongation factor B polypeptide 1
• UniProt Protein Name: Elongin-C
• Protein Family: Transcription elongation factor B polypeptide
• UniProt Gene Name: ELOC
• UniProt Synonym Gene Names: EloC

NCBI Description

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Uniprot Description

TCEB1: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Belongs to the SKP1 family.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: cytosol; nucleoplasm

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: positive regulation of RNA elongation from RNA polymerase II promoter; post-translational protein modification; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter