Eukaryotic translation initiation factor 4E-binding protein 2 Recombinant Protein | 4EBP2 recombinant protein

Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 2

Cat. Num. AAA9420204

• Gene Names: EIF4EBP2; 4EBP2; PHASII
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Eukaryotic translation initiation factor 4E-binding protein 2; Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 2; 4EBP2 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 1-120aa

• Tag Info: GST-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for 4EBP2 recombinant protein

Repressor of translation initiation involved in synaptic plasticity, learning and mory formation. Regulates EIF4E activity by preventing its assbly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal st cell renewal via its ability to repress translation initiation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

NCBI and Uniprot Product Information

• NCBI GI #: 4758260
• NCBI GeneID: 1979
• NCBI Accession #: NP_004087.1
• NCBI GenBank Nucleotide #: NM_004096.4
• UniProt Accession #: Q13542
• Molecular Weight: 40.3kD
• NCBI Official Full Name: eukaryotic translation initiation factor 4E-binding protein 2
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 4E binding protein 2
• NCBI Official Symbol: EIF4EBP2
• NCBI Official Synonym Symbols: 4EBP2; PHASII
• NCBI Protein Information: eukaryotic translation initiation factor 4E-binding protein 2
• UniProt Protein Name: Eukaryotic translation initiation factor 4E-binding protein 2
• Protein Family: Eukaryotic translation initiation factor 4E-binding protein
• UniProt Gene Name: EIF4EBP2
• UniProt Synonym Gene Names: eIF4E-binding protein 2

NCBI Description

This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]

Uniprot Description

4E-BP2: eukaryotic translation initiation factor 4E binding protein 2

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: cytoplasm

Molecular Function: eukaryotic initiation factor 4E binding; protein binding; translation repressor activity

Biological Process: memory; negative regulation of translational initiation; regulation of synaptic plasticity; regulation of synaptic transmission; social behavior; TOR signaling pathway; translation