Rabbit anti-Human, Rat IBA1 Polyclonal Antibody | anti-IBA1 antibody

IBA1 Antibody

Cat. Num. AAA9418458

• Gene Names: AIF1; IBA1; IRT1; AIF-1; IRT-1
• Reactivity: Human, Rat
• Applications: Western Blot
• Synonyms: IBA1; Polyclonal Antibody; IBA1 Antibody; AIF1; AIF-1; Em:AF129756.17; G1; IRT-1; Protein G1; IRT1; anti-IBA1 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Specificity: IBA1 Antibody detects endogenous levels of total IBA1
• Form/Format: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0mg/mL (varies by lot)
• Sequence Length: 93

• Applicable Applications for anti-IBA1 antibody: Western Blot (WB)
• Application Notes: Western Blot: 1:1000-3000
• Immunogen: A synthesized peptide derived from human IBA1
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis IBA1 using HeLa whole cell lysates)

Product Categories/Family for anti-IBA1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 974987466
• NCBI GeneID: 199
• NCBI Accession #: NP_001305899.1
• NCBI GenBank Nucleotide #: NM_001318970.1
• UniProt Accession #: P55008; O43904; Q9UIV4; Q9UKS9; A8K406
• Molecular Weight: 14,617 Da
• NCBI Official Full Name: allograft inflammatory factor 1 isoform 1
• NCBI Official Synonym Full Names: allograft inflammatory factor 1
• NCBI Official Symbol: AIF1
• NCBI Official Synonym Symbols: IBA1; IRT1; AIF-1; IRT-1
• NCBI Protein Information: allograft inflammatory factor 1
• UniProt Protein Name: Allograft inflammatory factor 1
• UniProt Gene Name: AIF1
• UniProt Synonym Gene Names: G1; IBA1; AIF-1
• UniProt Entry Name: AIF1_HUMAN

NCBI Description

This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016]

Uniprot Description

AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: actin filament; cytoplasm; cytosol; lamellipodium; nucleus; perinuclear region of cytoplasm; phagocytic cup

Molecular Function: actin filament binding; calcium ion binding

Biological Process: actin filament bundle formation; actin filament polymerization; inflammatory response; negative regulation of smooth muscle cell proliferation; phagocytosis, engulfment; positive regulation of smooth muscle cell proliferation; positive regulation of T cell proliferation; Rac protein signal transduction