Rabbit anti-Human, Mouse HNRNPU Polyclonal Antibody | anti-HNRNPU antibody

HNRNPU Antibody

Cat. Num. AAA9417064

• Gene Names: HNRNPU; SAFA; HNRPU; SAF-A; U21.1; hnRNP U; HNRNPU-AS1
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: HNRNPU; Polyclonal Antibody; HNRNPU Antibody; SAFA; HNRPU; SAF-A; U21.1; hnRNPU; HNRNPU-AS1; anti-HNRNPU antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total HNRNPU protein.
• Purity/Purification: Antigen affinity purification
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 0.5mg/ml (varies by lot)
• Sequence Length: 806

• Applicable Applications for anti-HNRNPU antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1: 20-100
• Immunogen: Synthetic peptide of human HNRNPU
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using HNRNPU Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200))

Related Product Information for anti-HNRNPU antibody

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.

Product Categories/Family for anti-HNRNPU antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 14141161
• NCBI GeneID: 3192
• NCBI Accession #: NP_004492.2
• NCBI GenBank Nucleotide #: NM_004501.3
• UniProt Accession #: Q00839; O75507; Q8N174; Q96HY9; Q9BQ09
• Molecular Weight: 88,980 Da
• NCBI Official Full Name: heterogeneous nuclear ribonucleoprotein U isoform b
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein U
• NCBI Official Symbol: HNRNPU
• NCBI Official Synonym Symbols: SAFA; HNRPU; SAF-A; U21.1; hnRNP U; HNRNPU-AS1
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein U
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein U
• Protein Family: Heterogeneous nuclear ribonucleoprotein
• UniProt Gene Name: HNRNPU
• UniProt Synonym Gene Names: HNRPU; SAFA; U21.1; hnRNP U; SAF-A
• UniProt Entry Name: HNRPU_HUMAN

NCBI Description

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

hnRNP U: Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor co-regulator; RNA splicing; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: extracellular matrix; membrane; nucleoplasm; nucleus; ribonucleoprotein complex; telomerase holoenzyme complex

Molecular Function: DNA binding; protein binding; RNA binding

Biological Process: circadian regulation of gene expression; gene expression; negative regulation of telomere maintenance via telomerase; nuclear mRNA splicing, via spliceosome; osteoblast differentiation; RNA processing