Western Blot (WB)
(All lanes: Peptidyl-prolyl cis-trans isomerase FKBP1A antibody at 2ug/ml)
Rabbit anti-Human Peptidyl-prolyl cis-trans isomerase FKBP1A Polyclonal Antibody | anti-FKBP1A antibody
Peptidyl-prolyl cis-trans isomerase FKBP1A Polyclonal Antibody
Immunohistochemistry: 1:20 - 1:200
Western Blot (WB)
(All lanes: Peptidyl-prolyl cis-trans isomerase FKBP1A antibody at 2ug/ml)
Western Blot (WB)
(All lanes: Peptidyl-prolyl cis-trans isomerase FKBP1A antibody at 2ug/ml)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embeded human kidney using at dilution of 1:50.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embeded human kidney using at dilution of 1:50.)
NCBI and Uniprot Product Information
Uniprot Description
FKBP12: an immunophilin and peptidyl-prolyl cis-trans isomerase that binds to the immunosuppressant drugs FK506 (a.k.a. tacrolimus or Fujimycin) and rapamycin (a.k.a. Sirolimus). The FKBP12/rapamycin complex binds NFAT transcription factors and inhibits the induction of T cell genes including IL-2, IL-3, IL-4, TNF-alpha and GM-CSF. FK506 is used in treating patients after organ transplant and those suffering from autoimmune disorders. The immunosuppressant activity of FKBP12 is not apparently related to its prolyl isomerase activity. The FKBP12/rapamycin complex inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding the mTOR Complex1 (mTORC1). mTORC1 contains Raptor, mLST8, and PRAS40, and interacts with DEPTOR, which inhibits its activity. mTOR, a S/T protein kinase, is a central regulator of cellular growth and metabolism. Its inhibition enhances the dependence on aerobic glycolysis in leukemic cells.
Protein type: EC 5.2.1.8; Isomerase
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; membrane; Z disc
Molecular Function: activin binding; calcium channel inhibitor activity; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; signal transducer activity; SMAD binding; transforming growth factor beta receptor binding
Biological Process: 'de novo' protein folding; fibril organization and biogenesis; heart morphogenesis; negative regulation of protein phosphatase type 2B activity; negative regulation of release of sequestered calcium ion into cytosol; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein binding; positive regulation of protein ubiquitination; protein maturation via protein folding; protein peptidyl-prolyl isomerization; protein refolding; regulation of activin receptor signaling pathway; regulation of immune response; regulation of protein localization; SMAD protein complex assembly; transforming growth factor beta receptor signaling pathway; ventricular cardiac muscle morphogenesis
Similar Products
Product Notes
The FKBP1A fkbp1a (Catalog #AAA9416077) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Peptidyl-prolyl cis-trans isomerase FKBP1A Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Peptidyl-prolyl cis-trans isomerase FKBP1A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western Blot: 1:500 - 1:1000 Immunohistochemistry: 1:20 - 1:200. Researchers should empirically determine the suitability of the FKBP1A fkbp1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Peptidyl-prolyl cis-trans isomerase FKBP1A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
