Rabbit anti-Human Nuclear receptor ROR-gamma Polyclonal Antibody | anti-RORC antibody

Nuclear receptor ROR-gamma Polyclonal Antibody

Cat. Num. AAA9415736

• Gene Names: RORC; TOR; RORG; RZRG; IMD42; NR1F3; RZR-GAMMA
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Synonyms: Nuclear receptor ROR-gamma; Polyclonal Antibody; Nuclear receptor ROR-gamma Polyclonal Antibody; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma; RORC; NR1F3; RORG; RZRG; anti-RORC antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total Nuclear receptor ROR-gamma polyclonal antibody.
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
• Form/Format: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 497

• Applicable Applications for anti-RORC antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:20 - 1:200
• Immunogen: Recombinant Human Nuclear receptor ROR-gamma protein£¨1-518aa£©
• Immunogen Type: Protein
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human breast cancer using at dilution of 1:100.)

Related Product Information for anti-RORC antibody

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A. Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1.

Product Categories/Family for anti-RORC antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 48255918
• NCBI GeneID: 6097
• NCBI Accession #: NP_001001523.1
• NCBI GenBank Nucleotide #: NM_001001523.1
• UniProt Accession #: P51449; Q5SZR9; Q8N5V7; Q8NCY8
• Molecular Weight: 55,813 Da
• NCBI Official Full Name: nuclear receptor ROR-gamma isoform b
• NCBI Official Synonym Full Names: RAR related orphan receptor C
• NCBI Official Symbol: RORC
• NCBI Official Synonym Symbols: TOR; RORG; RZRG; IMD42; NR1F3; RZR-GAMMA
• NCBI Protein Information: nuclear receptor ROR-gamma
• UniProt Protein Name: Nuclear receptor ROR-gamma
• Protein Family: Nuclear receptor
• UniProt Gene Name: RORC
• UniProt Synonym Gene Names: NR1F3; RORG; RZRG
• UniProt Entry Name: RORG_HUMAN

Uniprot Description

RORC: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor; Transcription factor

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus

Molecular Function: oxysterol binding; protein binding; transcription factor activity

Biological Process: circadian regulation of gene expression; positive regulation of circadian rhythm; positive regulation of transcription, DNA-dependent; regulation of fat cell differentiation; regulation of steroid metabolic process; transcription initiation from RNA polymerase II promoter; xenobiotic metabolic process

Disease: Immunodeficiency 42