Rabbit anti-Human, Mouse Slug Polyclonal Antibody | anti-Slug antibody

Slug Antibody

Cat. Num. AAA9409112

• Gene Names: SNAI2; SLUG; WS2D; SLUGH1; SNAIL2
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: Slug; Polyclonal Antibody; Slug Antibody; Neural crest transcription factor slug; Snail homolog 2; anti-Slug antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 268

• Applicable Applications for anti-Slug antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 14 amino acid peptide from near the center of human Slug.
• Target Name: Slug
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of Slug in human kidney cell lysate with Slug antibody at in (A) 1 and (B) 2 ug/mL.)

Related Product Information for anti-Slug antibody

Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.

Product Categories/Family for anti-Slug antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 11276067
• NCBI GeneID: 6591
• NCBI Accession #: NP_003059.1
• NCBI GenBank Nucleotide #: NM_003068.4
• UniProt Accession #: O43623; Q53FC1; B2R6P6
• Molecular Weight: 29,986 Da
• NCBI Official Full Name: zinc finger protein SNAI2
• NCBI Official Synonym Full Names: snail family zinc finger 2
• NCBI Official Symbol: SNAI2
• NCBI Official Synonym Symbols: SLUG; WS2D; SLUGH1; SNAIL2
• NCBI Protein Information: zinc finger protein SNAI2
• UniProt Protein Name: Zinc finger protein SNAI2
• UniProt Gene Name: SNAI2
• UniProt Synonym Gene Names: SLUG; SLUGH
• UniProt Entry Name: SNAI2_HUMAN

NCBI Description

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]

Uniprot Description

Snail2: Transcriptional repressor. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle. Belongs to the snail C2H2-type zinc-finger protein family.

Protein type: Motility/polarity/chemotaxis; C2H2-type zinc finger protein; Transcription factor; Apoptosis

Chromosomal Location of Human Ortholog: 8q11

Cellular Component: cytoplasm; nuclear chromatin; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; metal ion binding; chromatin binding

Biological Process: transcription from RNA polymerase II promoter; substrate-bound cell migration, cell release from substrate; Notch signaling pathway; regulation of osteoblast differentiation; neural crest cell development; negative regulation of chondrocyte differentiation; Wnt receptor signaling pathway through beta-catenin; palate development; negative regulation of transcription from RNA polymerase II promoter; osteoblast differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; sensory perception of sound; pigmentation; white fat cell differentiation; epithelial to mesenchymal transition; positive regulation of fat cell differentiation; positive regulation of histone acetylation; regulation of chemokine production; negative regulation of cell adhesion mediated by integrin; positive regulation of cell migration

Disease: Waardenburg Syndrome, Type 2d; Piebald Trait