Rabbit anti-Human, Mouse AGBL1 Polyclonal Antibody | anti-AGBL1 antibody

AGBL1 Antibody

Cat. Num. AAA9407907

• Gene Names: AGBL1; CCP4; FECD8
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: AGBL1; Polyclonal Antibody; AGBL1 Antibody; CBPC4; CCP4; FLJ32310; MGC149239; anti-AGBL1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total AGBL1 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 1066

• Applicable Applications for anti-AGBL1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:15-1:50
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the N terminal of human ATP/GTP binding protein-like 1
• Target Name: AGBL1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/15.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/15.)

Related Product Information for anti-AGBL1 antibody

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.

Product Categories/Family for anti-AGBL1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 120444924
• NCBI GeneID: 123624
• NCBI Accession #: NP_689549.2
• NCBI GenBank Nucleotide #: NM_152336.2
• UniProt Accession #: Q96MI9; A1A4X5; A6NJH6; C9JHL5
• Molecular Weight: 90,789 Da
• NCBI Official Full Name: cytosolic carboxypeptidase 4
• NCBI Official Synonym Full Names: ATP/GTP binding protein-like 1
• NCBI Official Symbol: AGBL1
• NCBI Official Synonym Symbols: CCP4; FECD8
• NCBI Protein Information: cytosolic carboxypeptidase 4
• UniProt Protein Name: Cytosolic carboxypeptidase 4
• Protein Family: Cytosolic carboxypeptidase
• UniProt Gene Name: AGBL1
• UniProt Synonym Gene Names: CCP4
• UniProt Entry Name: CBPC4_HUMAN

NCBI Description

Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy. [provided by RefSeq, Nov 2013]

Uniprot Description

AGBL1: Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Belongs to the peptidase M14 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.17.-

Chromosomal Location of Human Ortholog: 15q25.3

Cellular Component: cytosol

Molecular Function: tubulin binding; zinc ion binding; metallocarboxypeptidase activity

Biological Process: proteolysis

Disease: Corneal Dystrophy, Fuchs Endothelial, 8