Rabbit anti-Human ASIC1 Polyclonal Antibody | anti-ASIC1 antibody

ASIC1 Antibody

Cat. Num. AAA9404375

• Gene Names: ASIC1; ASIC; ACCN2; BNaC2
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: ASIC1; Polyclonal Antibody; ASIC1 Antibody; ASIC; ACCN2; BNaC2; anti-ASIC1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total ASIC1 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1.3 mg/ml (varies by lot)
• Sequence Length: 528

• Applicable Applications for anti-ASIC1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human acid-sensing (proton-gated) ion channel 1
• Target Name: ASIC1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/20.)

Related Product Information for anti-ASIC1 antibody

This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described.

Product Categories/Family for anti-ASIC1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 21536349
• NCBI GeneID: 41
• NCBI Accession #: NP_001086.2
• NCBI GenBank Nucleotide #: NM_001095.3
• UniProt Accession #: P78348; P78349; Q96CV2; A3KN86; E5KBL7
• Molecular Weight: 62,700 Da
• NCBI Official Full Name: acid-sensing ion channel 1 isoform b
• NCBI Official Synonym Full Names: acid sensing (proton gated) ion channel 1
• NCBI Official Symbol: ASIC1
• NCBI Official Synonym Symbols: ASIC; ACCN2; BNaC2
• NCBI Protein Information: acid-sensing ion channel 1
• UniProt Protein Name: Acid-sensing ion channel 1
• Protein Family: Acid-sensing ion channel
• UniProt Gene Name: ASIC1
• UniProt Synonym Gene Names: ACCN2; BNAC2; ASIC1; BNaC2
• UniProt Entry Name: ASIC1_HUMAN

NCBI Description

This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Uniprot Description

Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.