Rabbit TLK1 Polyclonal Antibody | anti-TLK1 antibody

TLK1 Antibody

Cat. Num. AAA9401906

• Gene Names: TLK1; PKU-beta
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: TLK1; Polyclonal Antibody; TLK1 Antibody; kinase TLK1; PKU-beta; tousled-like kinase 1; anti-TLK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total TLK1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 718

• Applicable Applications for anti-TLK1 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500~1:3000
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human TLK1.
• Target Name: TLK1
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from rat brain cells and NIH/3T3 cells, using TLK1 antibody.)

Related Product Information for anti-TLK1 antibody

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.Yamakawa A., Gene 202:193-201(1997).Sillje H.H.W., EMBO J. 18:5691-5702(1999).Cabaniols J.-P., Mol. Biol. Cell 10:4033-4041(1999).

Product Categories/Family for anti-TLK1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 211971036
• NCBI GeneID: 9874
• NCBI Accession #: NP_001130026.1
• NCBI GenBank Nucleotide #: NM_001136554.1
• UniProt Accession #: Q9UKI8; Q14150; Q8N591; Q9NYH2; Q9Y4F6; B3KR15; B4DX87
• Molecular Weight: 81,927 Da
• NCBI Official Full Name: serine/threonine-protein kinase tousled-like 1 isoform 2
• NCBI Official Synonym Full Names: tousled-like kinase 1
• NCBI Official Symbol: TLK1
• NCBI Official Synonym Symbols: PKU-beta
• NCBI Protein Information: serine/threonine-protein kinase tousled-like 1
• UniProt Protein Name: Serine/threonine-protein kinase tousled-like 1
• Protein Family: Serine/threonine-protein kinase tousled
• UniProt Gene Name: TLK1
• UniProt Synonym Gene Names: KIAA0137
• UniProt Entry Name: TLK1_HUMAN

NCBI Description

The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.