Bovine Very Long-Chain Acyl-CoA Synthetase (SLC27A2) ELISA Kit | SLC27A2 elisa kit
Bovine Very Long-Chain Acyl-CoA Synthetase (SLC27A2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Uniprot Description
SLC27A2: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.2.1.3; Ligase; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular exosome; integral component of endoplasmic reticulum membrane; integral to peroxisomal membrane; mitochondrion; peroxisomal membrane; plasma membrane
Molecular Function: ATP binding; enzyme binding; fatty acid transmembrane transporter activity; long-chain-fatty-acid-CoA ligase activity; phytanate-CoA ligase activity; receptor binding; very long-chain fatty acid-CoA ligase activity
Biological Process: bile acid biosynthetic process; fatty acid alpha-oxidation; fatty acid beta-oxidation; long-chain fatty acid import; long-chain fatty acid metabolic process; neutrophil degranulation; very-long-chain fatty acid catabolic process
Research Articles on SLC27A2
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Product Notes
The Bovine SLC27A2 slc27a2 (Catalog #AAA9398034) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9398034 ELISA Kit recognizes Bovine SLC27A2. It is sometimes possible for the material contained within the vial of "Very Long-Chain Acyl-CoA Synthetase (SLC27A2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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